Journal of Shanghai University(Natural Science Edition) ›› 2019, Vol. 25 ›› Issue (3): 365-374.doi: 10.12066/j.issn.1007-2861.2141

Special Issue: 精准与转化医学

Previous Articles     Next Articles

The proliferation and regulation of a adult mammalian cardiomyocytes

LIU Xiuxiu, ZHOU Bin()   

  1. State Key Laboratory of Cell Biology, Chinese Academic of Science Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academic of Sciences, Shanghai 200031, China
  • Received:2019-05-27 Online:2019-06-30 Published:2019-06-24
  • Contact: Bin ZHOU E-mail:zhoubin@sibs.ac.cn

Abstract:

Cardiomyocytes, a kind of completely differentiated cells, are believed not to be able to proliferate. Recent studies indicate, however, that adult mammalian cardiomyocytes turn over at a certain rate. These studies use different approaches including isotype incorporation and genetic knock-in mice lineage tracing. Cardiomyocyte proliferation may be regulated by complicated molecular network as well as varied environment or microenvironment. Special characteristic features in cardiomyocytes themselves also have an impact on their proliferation.

Key words: proliferation, cardiomyocyte, regulation, adult mammalian

CLC Number: