成体哺乳动物心肌细胞增殖及其调控

doi:10.12066/j.issn.1007-2861.2141

上海大学学报(自然科学版) ›› 2019, Vol. 25 ›› Issue (3): 365-374.doi: 10.12066/j.issn.1007-2861.2141

所属专题：精准与转化医学

成体哺乳动物心肌细胞增殖及其调控

刘秀秀, 周斌()

中国科学院中国科学院生物化学与细胞生物学研究所中国科学院分子细胞科学卓越创新中心细胞生物学国家重点实验室, 上海200031

收稿日期:2019-05-27 出版日期:2019-06-30 发布日期:2019-06-24
通讯作者: 周斌 E-mail:zhoubin@sibs.ac.cn
作者简介:周斌, 研究员,博士生导师. 国家自然科学基金杰出青年科学基金获得者,中科院“百人计划”,国家万人计划领军人才。
2002年7月毕业于浙江大学医学院临床医学系, 获得硕士学位. 2006年7月毕业于中国医学科学院中国协和医科大学, 获得博士学位. 2006年至2010年在美国哈佛大学医学院波士顿儿童医院从事博士后研究. 2009年任哈佛大学医学院讲师和Research Associate. 2010年9月至2016年8月任中国科学院上海生命科学研究院营养科学研究所研究员, 研究组长. 2016年9月起任职于中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员, 研究组长. 迄今以通信作者或第一作者身份发表SCI论文40余篇. 2014年, 周斌课题组在Science杂志上撰文《发现新生期心脏具有重新生成冠状动脉的能力》, 该研究成果入选“2014年度中国科学十大进展”. 曾获得中科院“百人计划”、国家自然科学基金杰出青年科学基金、国家万人计划领军人才、ISHR杰出研究员等. 代表性论文发表在Nature, Science, Nat Med, Nat Genet 等学术期刊上.
基金资助:
国家自然科学基金资助项目(31730112);国家自然科学基金资助项目(91639302);国家自然科学基金资助项目(31625019);国家自然科学基金资助项目(91849202);中国科学院战略性先导计划资助项目(XDB19000000);中国科学院战略性先导计划资助项目(XDA16020204)

The proliferation and regulation of a adult mammalian cardiomyocytes

LIU Xiuxiu, ZHOU Bin()

State Key Laboratory of Cell Biology, Chinese Academic of Science Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academic of Sciences, Shanghai 200031, China

Received:2019-05-27 Online:2019-06-30 Published:2019-06-24
Contact: Bin ZHOU E-mail:zhoubin@sibs.ac.cn

摘要/Abstract

摘要：

心肌细胞作为一种终末分化的细胞最初被认为不具备增殖的能力, 然而越来越多的证据表明, 成体的哺乳动物心脏中心肌细胞是以一定的比例进行更新换代的. 相关研究使用了不同的巧妙的方法, 包括同位素的掺入以及遗传工具小鼠的使用. 心肌细胞的增殖受到复杂的分子网络的调控, 同时也受到外界环境及内部微环境的调控. 心肌细胞自身具有的特性也是影响心肌细胞增殖的关键.

关键词: 增殖, 心肌细胞, 调控, 成体哺乳动物

Abstract:

Cardiomyocytes, a kind of completely differentiated cells, are believed not to be able to proliferate. Recent studies indicate, however, that adult mammalian cardiomyocytes turn over at a certain rate. These studies use different approaches including isotype incorporation and genetic knock-in mice lineage tracing. Cardiomyocyte proliferation may be regulated by complicated molecular network as well as varied environment or microenvironment. Special characteristic features in cardiomyocytes themselves also have an impact on their proliferation.

Key words: proliferation, cardiomyocyte, regulation, adult mammalian

中图分类号:

R541

刘秀秀, 周斌. 成体哺乳动物心肌细胞增殖及其调控[J]. 上海大学学报(自然科学版), 2019, 25(3): 365-374.

LIU Xiuxiu , ZHOU Bin. The proliferation and regulation of a adult mammalian cardiomyocytes[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 365-374.

参考文献 68

[1]	Narula J, Haider N, Virmani R , et al. Apoptosis in myocytes in end-stage heart failure[J]. New Engl J Med, 1996,335(16):1182-1189. doi: 10.1056/NEJM199610173351603 pmid: 8815940
[2]	Mark K K K, Soonpaa H, Pajak L , et al. Cardiomyocyte DNA synjournal and binucleation during murine development[J]. Am J Physiol Heart Circ Physiol, 1996,271(5):H2183-H2189. doi: 10.3389/fcell.2016.00137 pmid: 28018900
[3]	Hsieh P C, Segers V F, Davis M E , et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury[J]. Nat Med, 2007,13(8):970-974. doi: 10.1038/nm1618 pmid: 17660827
[4]	Bergmann O, Bhardwaj R D, Bernard S , et al. Evidence for cardiomyocyte renewal in humans[J]. Science, 2009,324(5923):98-102. doi: 10.1126/science.1164680 pmid: 19342590
[5]	Bergmann O, Zdunek S, Felker A , et al. Dynamics of cell generation and turnover in the human heart[J]. Cell, 2015,161(7):1566-1575. doi: 10.1016/j.cell.2015.05.026 pmid: 26073943
[6]	Beltrami A P, Urbanek K, Kajstura J , et al. Evidence that human cardiac myocytes divide after myocardial infarction[J]. New Engl J Med, 2001,344(23):1750-1757. doi: 10.1056/NEJM200106073442303 pmid: 11396441
[7]	Kajstura J, Urbanek K, Perl S , et al. Cardiomyogenesis in the adult human heart[J]. Circ Res, 2010,107(2):305-315. doi: 10.1161/CIRCRESAHA.110.223024 pmid: 20522802
[8]	Steinhauser M L, Bailey A P, Senyo S E , et al. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism[J]. Nature, 2012,481(7382):516-519. doi: 10.1038/nature10734
[9]	Senyo S E, Steinhauser M L, Pizzimenti C L , et al. Mammalian heart renewal by pre-existing cardiomyocytes[J]. Nature, 2013,493(7432):433-436. doi: 10.1038/nature11682
[10]	Zong H, Espinosa J S, Su H H , et al. Mosaic analysis with double markers in mice[J]. Cell, 2005,121(3):479-492. doi: 10.1016/j.cell.2005.02.012 pmid: 15882628
[11]	Ali S R, Hippenmeyer S, Saadat L V , et al. Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice[J]. Proc Natl Acad Sci U S A, 2014,111(24):8850-8855. doi: 10.1073/pnas.1408233111 pmid: 24876275
[12]	Sereti K I, Nguyen N B, Kamran P , et al. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury[J]. Nature Communications, 2018,9(1):754. doi: 10.1038/s41467-018-02891-z pmid: 29467410
[13]	Basak O, Van De Born M, Korving J, et al. Mapping early fate determination in Lgr5$^{+}$ crypt stem cells using a novel Ki67-RFP allele[J]. EMBO J, 2014,33(18):2057-2068. doi: 10.15252/embj.201488017
[14]	Basak O, Krieger T G, Muraro M J , et al. Troy$^{+}$ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy[J]. Proc Natl Acad Sci U S A, 2018,115(4):E610-E619. doi: 10.1073/pnas.1715911114 pmid: 29311336
[15]	Kretzschmar K, Post Y, Bannier-Helaouet M , et al. Profiling proliferative cells and their progeny in damaged murine hearts[J]. Proc Natl Acad Sci U S A, 2018,115(52):E12245-E12254. doi: 10.1073/pnas.1805829115 pmid: 30530645
[16]	He L, Li Y, Li Y , et al. Enhancing the precision of genetic lineage tracing using dual recombinases[J]. Nat Med, 2017,23(12):1488-1498. doi: 10.1038/nm.4437 pmid: 29131159
[17]	Li Y, He L, Huang X , et al. Genetic lineage tracing of nonmyocyte population by dual recombinases[J]. Circulation, 2018,138(8):793-805. doi: 10.1161/CIRCULATIONAHA.118.034250 pmid: 29700121
[18]	Naqvi N, Li M, Calvert J W , et al. A proliferative burst during preadolescence establishes the final cardiomyocyte number[J]. Cell, 2014,157(4):795-807. doi: 10.1016/j.cell.2014.03.035
[19]	Soonpaa M H, Zebrowski D C, Platt C , et al. Cardiomyocyte cell-cycle activity during preadolescence[J]. Cell, 2015,163(4):781-782. doi: 10.1016/j.cell.2015.10.037 pmid: 26544927
[20]	Alkass K, Panula J, Westman M , et al. No evidence for cardiomyocyte number expansion in preadolescent mice[J]. Cell, 2015,163(4):1026-1036. doi: 10.1016/j.cell.2015.10.035 pmid: 26544945
[21]	Chaudhry H W, Dashoush N H, Tang H , et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium[J]. J Biol Chem, 2004,279(34):35858-35866. doi: 10.1074/jbc.M404975200 pmid: 15159393
[22]	Cheng R K, Asai T, Tang H , et al. Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure[J]. Circulation Research, 2007,100(12):1741-1748. doi: 10.1161/CIRCRESAHA.107.153544 pmid: 17495221
[23]	Shapiro S D, Ranjan A K, Kawase Y , et al. Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes [J]. Sci Transl Med, 2014, 6(224): 224ra27.
[24]	Mohamed T M A, Ang Y S, Radzinsky E , et al. Regulation of cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration[J]. Cell, 2018,173(1):104-116. doi: 10.1016/j.cell.2018.02.014 pmid: 29502971
[25]	Zhang D, Wang Y, Lu P , et al. REST regulates the cell cycle for cardiac development and regeneration[J]. Nature Communications, 2017,8(1):1979. doi: 10.1038/s41467-017-02210-y pmid: 29215012
[26]	Pan D J . The hippo signaling pathway in development and cancer[J]. Developmental Cell, 2010,19(4):491-505. doi: 10.1016/j.devcel.2010.09.011
[27]	Zhao B, Tumaneng K, Guan K L . The hippo pathway in organ size control, tissue regeneration and stem cell self-renewal[J]. Nat Cell Biol, 2011,13(8):877-883. doi: 10.1038/ncb2303 pmid: 21808241
[28]	Heallen T, Zhang M, Wang J , et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size[J]. Science, 2011,332(6028):458-461. doi: 10.1126/science.1201182
[29]	Xin M, Kim Y, Sutherland L B , et al. Hippo pathway effector Yap promotes cardiac regeneration[J]. Proc Natl Acad Sci USA, 2013,110(34):13839-13844. doi: 10.1073/pnas.1313192110 pmid: 23918388
[30]	Lin Z, Von Gise A, Zhou P , et al. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model[J]. Circ Res, 2014,115(3):354-363. doi: 10.1161/CIRCRESAHA.115.303632
[31]	Monroe T O, Hill M C, Morikawa Y , et al. YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis in vivo[J]. Dev Cell, 2019,48(6):765-779. doi: 10.1016/j.devcel.2019.01.017 pmid: 30773489
[32]	Xiang F L, Guo M, Yutzey K E . Overexpression of Tbx20 in adult cardiomyocytes promotes proliferation and improves cardiac function after myocardial infarction[J]. Circulation, 2016,133(11):1081-1092. doi: 10.1161/CIRCULATIONAHA.115.019357 pmid: 26841808
[33]	Hang C T, Yang J, Han P , et al. Chromatin regulation by Brg1 underlies heart muscle development and disease[J]. Nature, 2010,466(7302):62-67. doi: 10.1038/nature09130 pmid: 20596014
[34]	D'Uva G, Aharonov A, Lauriola M, et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation[J]. Nat Cell Biol, 2015,17(5):627-638. doi: 10.1038/ncb3149 pmid: 25848746
[35]	Bersell K, Arab S, Haring B , et al. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury[J]. Cell, 2009,138(2):257-270. doi: 10.1016/j.cell.2009.04.060 pmid: 19632177
[36]	Mahmoud A I, Kocabas F, Muralidhar S A , et al. Meis1 regulates postnatal cardiomyocyte cell cycle arrest[J]. Nature, 2013,497(7448):249-253. doi: 10.1038/nature12054 pmid: 23594737
[37]	Van Rooij E . The art of microRNA research[J]. Circ Res, 2011,108(2):219-234. doi: 10.1161/CIRCRESAHA.110.227496
[38]	Farh K K H, Grimson A, Jan C , et al. The widespread impact of mammalian microRNAs on mRNA repression and evolution[J]. Science, 2005,310(5755):1817-1821. doi: 10.1126/science.1121158 pmid: 16308420
[39]	Eulalio A, Mano M, Dal Ferro M , et al. Functional screening identifies miRNAs inducing cardiac regeneration[J]. Nature, 2012,492(7429):376-381. doi: 10.1038/nature11739
[40]	Giacca M, Zacchigna S . Harnessing the microRNA pathway for cardiac regeneration[J]. J Mol Cell Cardiol, 2015,89(PtA):68-74. doi: 10.1016/j.yjmcc.2015.09.017 pmid: 26431632
[41]	Aguirre A, Montserrat N, Zacchigna S , et al. In vivo activation of a conserved microRNA program induces mammalian heart regeneration[J]. Cell Stem Cell, 2014,15(5):589-604. doi: 10.1016/j.stem.2014.10.003
[42]	Diez-Cunado M, Wei K, Bushway P J , et al. MiRNAs that induce human cardiomyocyte proliferation converge on the hippo pathway[J]. Cell Rep, 2018,23(7):2168-2174. doi: 10.1016/j.celrep.2018.04.049 pmid: 29768213
[43]	Gabisonia K, Prosdocimo G, Aquaro G D , et al. MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs[J]. Nature, 2019,569(7756):418-422. doi: 10.1038/s41586-019-1191-6 pmid: 31068698
[44]	Parmar K, Mauch P, Vergilio J A , et al. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia[J]. Proc Natl Acad Sci U S A, 2007,104(13):5431-5436. doi: 10.1073/pnas.0701152104 pmid: 17374716
[45]	Mazumdar J, O'Brien W T, Johnson R S, et al. O2 regulates stem cells through Wnt/beta-catenin signalling[J]. Nat Cell Biol, 2010,12(10):1007-1013. doi: 10.1038/ncb2102 pmid: 20852629
[46]	Kimura W, Xiao F, Canseco D C , et al. Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart[J]. Nature, 2015,523(7559):226-230. doi: 10.1038/nature14582 pmid: 26098368
[47]	Nakada Y, Canseco D C, Thet S , et al. Hypoxia induces heart regeneration in adult mice[J]. Nature, 2017,541(7636):222-227. doi: 10.1038/nature20173 pmid: 27798600
[48]	Puente B N, Kimura W, Muralidhar S A , et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response[J]. Cell, 2014,157(3):565-579. doi: 10.1016/j.cell.2014.03.032
[49]	Zacchigna S, Martinelli V, Moimas S , et al. Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction[J]. Nature Communications, 2018,9(1):2432. doi: 10.1038/s41467-018-04908-z pmid: 29946151
[50]	Jutel M, Akdis M, Budak F , et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy[J]. Eur J Immunol, 2003,33(5):1205-1214. doi: 10.1002/eji.200322919 pmid: 12731045
[51]	Figueiredo A S, Schumacher A . The T helper type 17/regulatory T cell paradigm in pregnancy[J]. Immunology, 2016,148(1):13-21. doi: 10.1111/imm.12595 pmid: 26855005
[52]	Tao L C, Bei Y H, Zhang H F , et al. Exercise for the heart: signaling pathways[J]. Oncotarget, 2015,6(25):20773-20784. doi: 10.18632/oncotarget.4770 pmid: 26318584
[53]	Ellison G M, Waring C D, Vicinanza C , et al. Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms[J]. Heart, 2012,98(1):5-10. doi: 10.1136/heartjnl-2011-300639
[54]	Vujic A, Lerchenmuller C, Wu T D , et al. Exercise induces new cardiomyocyte generation in the adult mammalian heart[J]. Nature Communications, 2018,9(1):1659. doi: 10.1038/s41467-018-04083-1 pmid: 29695718
[55]	Bostrom P, Mann N, Wu J , et al. C/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling[J]. Cell, 2010,143(7):1072-1083. doi: 10.1016/j.cell.2010.11.036 pmid: 21183071
[56]	He S, Sharpless N E . Senescence in health and disease[J]. Cell, 2017,169(6):1000-1011. doi: 10.1016/j.cell.2017.05.015 pmid: 28575665
[57]	Yun M H, Davaapil H, Brockes J P . Recurrent turnover of senescent cells during regeneration of a complex structure[J]. Elife, 2015, DOI: 10.7554/eLife.05505. doi: 10.7554/eLife.50087 pmid: 31794382
[58]	Ritschka B, Storer M, Mas A , et al. The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration[J]. Genes Dev, 2017,31(2):172-183. doi: 10.1101/gad.290635.116 pmid: 28143833
[59]	Feng T, Meng J, Kou S , et al. CCN1-induced cellular senescence promotes heart regeneration[J]. Circulation, 2019,139(21):2495-2498. doi: 10.1161/CIRCULATIONAHA.119.039530 pmid: 31107624
[60]	Sarig R, Rimmer R, Bassat E , et al. Transient p53-mediated regenerative senescence in the injured heart[J]. Circulation, 2019,139(21):2491-2494. doi: 10.1161/CIRCULATIONAHA.119.040125 pmid: 31107623
[61]	Davoli T, De Lange T . The causes and consequences of polyploidy in normal development and cancer[J]. Annu Rev Cell Dev Biol, 2011,27:585-610. doi: 10.1146/annurev-cellbio-092910-154234 pmid: 21801013
[62]	Duncan A W, Taylor M H, Hickey R D , et al. The ploidy conveyor of mature hepatocytes as a source of genetic variation[J]. Nature, 2010,467(7316):707-710. doi: 10.1038/nature09414 pmid: 20861837
[63]	Kikuchi K . Advances in understanding the mechanism of zebrafish heart regeneration[J]. Stem Cell Res, 2014,13(3):542-555. doi: 10.1016/j.scr.2014.07.003 pmid: 25127427
[64]	Vivien C J, Hudson J E, Porrello E R . Evolution, comparative biology and ontogeny of vertebrate heart regeneration[J]. NPJ Regen Med, 2016, DOI: 10.1038/npjregenmed.2016.12. doi: 10.1038/s41536-019-0084-5 pmid: 31754462
[65]	Brodsky V, Sarkisov D S, Arefyeva A M , et al. Polyploidy in cardiac myocytes of normal and hypertrophic human hearts; range of values[J]. Virchows Arch, 1994,424(4):429-435. doi: 10.1007/bf00190566 pmid: 8205355
[66]	Gonzalez-Rosa J M, Sharpe M, Field D , et al. Myocardial polyploidization creates a barrier to heart regeneration in zebrafish[J]. Dev Cell, 2018,44(4):433-446. doi: 10.1016/j.devcel.2018.01.021 pmid: 29486195
[67]	Hirose K, Payumo A Y, Cutie S , et al. Evidence for hormonal control of heart regenerative capacity during endothermy acquisition[J]. Science, 2019,364(6436):184-188. doi: 10.1126/science.aar2038 pmid: 30846611
[68]	Tzahor E, Poss K D . Cardiac regeneration strategies: stayingyoung at heart[J]. Science, 2017,356(6342):1035-1039. doi: 10.1126/science.aam5894 pmid: 28596337

成体哺乳动物心肌细胞增殖及其调控

The proliferation and regulation of a adult mammalian cardiomyocytes

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 68

相关文章 15

编辑推荐

Metrics

本文评价

[1]	丁杨楠, 吕双杰, 陈厚早, 刘德培. 血管衰老中的表观遗传调控[J]. 上海大学学报(自然科学版), 2019, 25(3): 381-388.
[2]	董妍涵, 王昆. 非编码RNA在调控心脏细胞死亡相关的心血管疾病中的作用[J]. 上海大学学报(自然科学版), 2019, 25(3): 389-398.
[3]	朱宏文, 喻溥蛟, 许嘉鸿. miR-19b 通过激活 Akt 信号通路保护心肌细胞凋亡[J]. 上海大学学报(自然科学版), 2019, 25(1): 10-17.
[4]	苏杭, 王保垒, 李华顺, 朱晨光. Numb基因不同亚型对乳腺癌细胞MCF-7增殖和迁移能力的影响[J]. 上海大学学报(自然科学版), 2018, 24(3): 476-485.
[5]	陈欣欣, 刘珠媛, 顾寰宇, 周蕾. 人类胚胎干细胞来源的心肌细胞模型的建立及系统鉴定方案[J]. 上海大学学报(自然科学版), 2017, 23(3): 378-386.
[6]	朱浩1, 丁胜光1, 黄海涛1, 许嘉鸿2, 仲崇俊1. 新生大鼠心脏再生模型的改良及评价模式[J]. 上海大学学报(自然科学版), 2017, 23(3): 387-394.
[7]	刘仕进, 刘艳伟, 王瑞琦. 基于分层网络和反馈机制的细胞重编程[J]. 上海大学学报(自然科学版), 2016, 22(5): 552-559.
[8]	肖珍, 朱杰宁, 唐春梅, 林秋雄, 胡志琴, 张灼, 符永恒, 张梦珍, 单志新. 巨噬细胞移动抑制因子缺失加重苯肾上腺素诱导的小鼠心肌肥厚[J]. 上海大学学报(自然科学版), 2016, 22(3): 336-343.
[9]	贝毅桦, 肖俊杰. 运动诱导心脏再生: 治疗心血管疾病的新途径[J]. 上海大学学报(自然科学版), 2016, 22(3): 293-301.
[10]	何志敏1, 马文丽1,2, 郑文岭1,3. 沉默SEMA3A基因对胶质瘤细胞U251增殖和转移的影响[J]. 上海大学学报(自然科学版), 2015, 21(2): 237-244.
[11]	胡宗1, 梁桑华2, 马文丽1,2, 郑文岭1,3. PinX1基因真核表达载体的构建及其对乳腺癌MCF-7细胞增殖的抑制作用[J]. 上海大学学报(自然科学版), 2013, 19(6): 631-635.
[12]	康佳, 雷炳莉, 刘倩, 王学彤, 吴明红, 徐刚, 傅家谟. 上海河流沉积物的有机提取物对3 种细胞的毒性效应[J]. 上海大学学报(自然科学版), 2013, 19(4): 393-399.
[13]	马立新, 江霓, 袁淑娟. 负荷跟踪型发电系统协调控制方式的智能化[J]. 上海大学学报(自然科学版), 2013, 19(2): 144-149.
[14]	张志勇,徐凤丹. p53振子的形成机制及microRNA对p53目标基因表达的精细调控[J]. 上海大学学报(自然科学版), 2011, 17(5): 631-635.
[15]	颜婷婷，张登松，施利毅. 纳米结构材料的制备及应用进展[J]. 上海大学学报(自然科学版), 2011, 17(4): 447-457.