血管衰老中的表观遗传调控

doi:10.12066/j.issn.1007-2861.2138

上海大学学报(自然科学版) ›› 2019, Vol. 25 ›› Issue (3): 381-388.doi: 10.12066/j.issn.1007-2861.2138

所属专题：精准与转化医学

血管衰老中的表观遗传调控

丁杨楠, 吕双杰, 陈厚早(), 刘德培

中国医学科学院北京协和医学院基础医学研究所医学分子生物学国家重点实验室, 北京 100005

收稿日期:2019-04-22 出版日期:2019-06-30 发布日期:2019-06-24
通讯作者: 陈厚早 E-mail:chenhouzao@ibms.cams.cn
作者简介:陈厚早,男，研究员,博士生导师,国家自然科学基金委优秀青年科学基金获得者,教育部长江学者奖励计划青年长江学者,中组部青年拔尖人才,国家万人计划领军人物。
北京协和医院生物化学与分子生物学专业博士,中国医学科学院基础医学研究所研究员, 博士生导师,主要从事衰老相关心血管疾病的表观遗传机制研究, 系统阐述了表观修饰酶SIRTuins家族分子在心血管疾病中的作用,可望成为防治衰老相关心血管疾病的潜在靶点. 到目前为止,共发表SCI研究论文和综述文章等50余篇, 总影响因子逾400分.以通信或第一作者(含共同)发表在J Clin Invest, J ExpMed, Circ, Eur Heart J, Cir Res, AgingCell 等国际知名杂志论文30余篇, 被引2 000余次.获国家自然科学基金委优秀青年科学基金、中组部青年拔尖人才、教育部长江学者奖励计划青年长江学者和国家万人计划领军人才等荣誉或资助.
基金资助:
中国医学科学院医学表观遗传研究中心资助项目(2017PT31035);中国医学科学院医学表观遗传研究中心资助项目(2018PT31015)

Epigenetic regulation in vascular aging

DING Yangnan, LÜ Shuangjie, CHEN Houzao(), LIU Depei

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China

Received:2019-04-22 Online:2019-06-30 Published:2019-06-24
Contact: Houzao CHEN E-mail:chenhouzao@ibms.cams.cn

摘要/Abstract

摘要：

血管衰老是伴随年龄增长而出现的血管结构和功能的改变, 主要包括血管重塑、血管稳态失衡以及血管细胞的衰老. 表观遗传调控是在不改变DNA 序列的情况下改变基因的表达, 其主要机制包括DNA 甲基化、组蛋白修饰以及非编码RNA 的调控等. 目前的研究表明各种表观遗传调控途径参与血管衰老的各个层面, 在血管衰老及相关疾病的发生发展中扮演重要角色. 靶向表观遗传调控的药物有望成为衰老相关疾病新的治疗方向.

关键词: 血管衰老, 表观遗传调控, DNA 甲基化, 组蛋白修饰, 非编码RNA, Senescaging

Abstract:

Vascular aging refers to the structural and functional changes of aorta during the aging process. It is characterized by vascular remodeling, vascular dyshomeostasis and vascular cell senescence. Epigenetic regulation can influence gene expression without changing the DNA sequence and it mainly includes DNA methylation, histone modifications, and RNA-based gene regulation. Current researches demonstrate that epigenetic regulation plays important roles in vascular aging and age-related diseases, and drugs targeting epigenetic regulation are expected to be new treatments for age-related diseases.

Key words: vascular aging, epigenetic regulation, DNA methylation, histone modification, non-coding RNAs, Senescaging

中图分类号:

丁杨楠, 吕双杰, 陈厚早, 刘德培. 血管衰老中的表观遗传调控[J]. 上海大学学报(自然科学版), 2019, 25(3): 381-388.

DING Yangnan , LÜ Shuangjie , CHEN Houzao , LIU Depei . Epigenetic regulation in vascular aging[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 381-388.

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血管衰老中的表观遗传调控

Epigenetic regulation in vascular aging

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