非编码RNA与心肌重构

doi:10.3969/j.issn.1007-2861.2016.04.002

上海大学学报(自然科学版) ›› 2016, Vol. 22 ›› Issue (3): 310-317.doi: 10.3969/j.issn.1007-2861.2016.04.002

非编码RNA与心肌重构

王建勋1, 高金宁1, 丁巍2

1. 青岛大学转化医学研究院, 山东青岛266021;
2. 青岛大学附属医院综合内科, 山东青岛266021

收稿日期:2016-04-27 出版日期:2016-06-30 发布日期:2016-06-30
通讯作者: 王建勋(1978—), 男, 副教授, 博士, 研究方向为心脏疾病分子机制. E-mail: wangjx@qdu.edu.cn
作者简介:王建勋(1978—), 男, 副教授, 博士, 研究方向为心脏疾病分子机制. E-mail: wangjx@qdu.edu.cn
基金资助:
国家自然科学基金资助项目(81370262)

Non-coding RNAs and myocardial remodeling

WANG Jianxun1, GAO Jinning1, DING Wei2

1. Institute for Translational Medicine, Qingdao University, Qingdao 266021, Shandong, China;
2. Department of Comprehensive Internal Medicine, Affiliated Hospital of Qingdao University, Qingdao 266021, Shandong, China

Received:2016-04-27 Online:2016-06-30 Published:2016-06-30

摘要/Abstract

摘要：

非编码RNA(non-coding RNAs, ncRNAs) 是一类不编码蛋白质的RNA 分子. 相关研究表明, ncRNAs 不仅参与细胞的增殖、凋亡、分化、代谢等生理过程, 还参与疾病的病理过程. 心肌重构(myocardial remodeling)是多种心血管疾病最主要的病理基础. 已有多项研究表明, 心肌重构的发生发展与ncRNAs 的调控息息相关, 近年来针对ncRNAs 在心脏疾病方面的研究也得到了迅猛发展. 对ncRNAs 包括微小RNA(microRNAs, miRNAs)、长链非编码RNA(long non-coding RNAs, lncRNAs)和环形RNA(circular RNAs, circRNAs) 与心肌重构的最新研究进展以及作用机制进行介绍, 旨在寻找新的心脏疾病治疗靶点.

关键词: 长链非编码RNA , 环形RNA , 微小RNA , 心肌重构, 非编码RNA

Abstract:

Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. Studies show that ncRNAs are not only involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also in pathogenesis of diseases. Myocardial remodeling is the main pathological basis of a variety of cardiovascular diseases. Many studies have shown that occurrence and development of myocardial remodeling are closely related to the regulation of ncRNAs. Recent researches of ncRNAs in heart disease have achieved rapid advances. Aimed to look for new targets for heart disease treatment, this paper systematically introduces the latest research progress, mainly in the mechanism of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in myocardial remodeling.

Key words: cardiac remodeling, circular RNAs (circRNAs) , long non-coding RNAs(lncRNAs) , microRNAs (miRNAs) , non-coding RNAs (ncRNAs)

王建勋1, 高金宁1, 丁巍2. 非编码RNA与心肌重构[J]. 上海大学学报(自然科学版), 2016, 22(3): 310-317.

WANG Jianxun1, GAO Jinning1, DING Wei2. Non-coding RNAs and myocardial remodeling[J]. Journal of Shanghai University（Natural Science Edition）, 2016, 22(3): 310-317.

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非编码RNA与心肌重构

Non-coding RNAs and myocardial remodeling

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