非编码RNA调控心脏重构与再生

doi:10.3969/j.issn.1007-2861.2016.03.021

上海大学学报(自然科学版) ›› 2016, Vol. 22 ›› Issue (3): 302-309.doi: 10.3969/j.issn.1007-2861.2016.03.021

非编码RNA调控心脏重构与再生

高峰1,2, 陈静海1,2

1. 浙江大学医学院附属第二医院浙江省心血管病诊治重点实验室, 杭州310009;
2. 浙江大学转化医学研究院, 杭州310029

收稿日期:2016-04-22 出版日期:2016-06-30 发布日期:2016-06-30
通讯作者: 陈静海(1978—), 男, 研究员, 博士生导师, 博士, 研究方向为非编码核酸调控心血管疾病与再生. E-mail: Jinghaichen@zju.edu.cn
作者简介:陈静海(1978—), 男, 研究员, 博士生导师, 博士, 研究方向为非编码核酸调控心血管疾病与再生. E-mail: Jinghaichen@zju.edu.cn
基金资助:
国家自然科学基金资助项目(81470382)

Non-coding RNAs mediate cardiac remodeling and regeneration

GAO Feng1,2, CHEN Jinghai1,2

1. Provincial Key Laboratory of Cardiovascular Research, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China;
2. Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China

Received:2016-04-22 Online:2016-06-30 Published:2016-06-30

摘要/Abstract

摘要：

近年来, 越来越多的证据表明, 大量的非编码RNA(non-coding RNAs, ncRNAs)在基因的表达调控、细胞和机体的生理功能维持与病理环境调节方面都有重要作用, 其中主要包括微小RNA(microRNAs, miRNAs) 和长链非编码RNA(long non-coding RNAs, lncRNAs).心脏重构与再生是心血管疾病领域的关键问题, 其调控过程非常复杂, 包括表观遗传、转录、转录后及翻译水平的调控. 大量研究发现在转录后水平, miRNAs 通过负性调节靶标的表达调控心脏发育、疾病及再生进程. 近期研究揭示, lncRNAs 在心脏发育和疾病中具有潜在的作用, 可通过表观遗传、转录及转录后水平发挥作用. lncRNAs 已成为继miRNAs 之后的又一重要的调节性非编码RNA. 就非编码RNA 在心脏重构及再生进程中的调控作用进行综述.

关键词: 长链非编码RNA , 心脏再生, 心脏重构 , 微小RNA

Abstract:

Recently, more and more evidences indicate that a large number of non-coding RNAs (ncRNAs) are involved in gene expression, physiological and pathological regulation, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Cardiac remodeling and regeneration are key to cardiovascular biology and diseases. Regulation of gene expression during cardiac remodeling and regeneration is complicated, involving epigenetic, transcriptional, post-transcriptional and translational regulation. In the past decade, miRNAs have drawn much attention for their impact on cardiovascular diseases and regeneration. miRNAs negatively regulate the expression of the target genes through post-transcriptional regulation. Recent research uncovered that lncRNAs play an important role in cardiac development and diseases, involving epigenetic, transcriptional and post-transcriptional regulation, making lncRNAs become another group of key regulatory non-coding RNAs. This paper summarizes the recent progress in the study of non-coding RNAs in cardiac remodeling and cardiac regeneration.

Key words: cardiac regeneration, cardiac remodeling , long non-coding RNAs (lncRNAs) , microRNAs (miRNAs)

高峰1,2, 陈静海1,2. 非编码RNA调控心脏重构与再生[J]. 上海大学学报(自然科学版), 2016, 22(3): 302-309.

GAO Feng1,2, CHEN Jinghai1,2. Non-coding RNAs mediate cardiac remodeling and regeneration[J]. Journal of Shanghai University（Natural Science Edition）, 2016, 22(3): 302-309.

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非编码RNA调控心脏重构与再生

Non-coding RNAs mediate cardiac remodeling and regeneration

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