非编码RNA在调控心脏细胞死亡相关的心血管疾病中的作用

doi:10.12066/j.issn.1007-2861.2137

上海大学学报(自然科学版) ›› 2019, Vol. 25 ›› Issue (3): 389-398.doi: 10.12066/j.issn.1007-2861.2137

所属专题：精准与转化医学

非编码RNA在调控心脏细胞死亡相关的心血管疾病中的作用

董妍涵, 王昆()

青岛大学转化医学研究院, 山东青岛 266021

收稿日期:2019-04-10 出版日期:2019-06-30 发布日期:2019-06-24
通讯作者: 王昆 E-mail:wangk696@163.com
作者简介:王昆, 教授，博士生导师，国家自然科学基金委优秀青年科学基金获得者，山东省自然科学杰出青年基金获得者。
青岛大学特聘教授, 博士生导师,青岛大学转化医学院发育心脏病学中心主任.2015年国家优秀青年基金获得者,2016年山东省自然科学杰出青年基金获得者. 目前为止,已有多项研究成果发表在国际期刊Circulation, European Heart Journal, Circulation Research, Nature Communications, Gene & Development, PNAS, Cell Death & Differentiation, PLoS Genetics上. 已发表SCI论文20余篇.现担任多个学术杂志审稿人及国家自然科学基金委评审专家.先后主持国家自然科学优秀青年基金1项、国家自然科学面上项目2项、国家自然科学青年基金1项、北京市面上项目1项. 参与了包括国家重点项目及重大国际合作项目等 8项国家基金项目的工作.曾获东方心脏病学大会东方新星奖、第十届青岛市青年科技奖、中国科学院卢嘉锡青年人才奖、中华医学科技奖二等奖及北京市科学技术奖三等奖.2014年入选中国科学院青年创新促进会会员.
基金资助:
青岛应用基础研究资助项目(17-1-1-46-jch);山东省自然科学青年基金资助项目(ZR2016CQ31)

Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases

DONG Yanhan,WANG Kun()

Institute for Translational Medicine, Qingdao University, Shandong Qingdao 266021, China

Received:2019-04-10 Online:2019-06-30 Published:2019-06-24
Contact: Kun WANG E-mail:wangk696@163.com

摘要/Abstract

摘要：

鉴于成年心脏中心肌细胞的再生能力有限,使得功能性心肌细胞的丧失成为心肌重塑相关的心血管疾病的主要原因.细胞凋亡、自噬和坏死过程涉及多个复杂的信号通路,控制着心肌细胞死亡和细胞存活的平衡, 导致心肌细胞的损失. 近年发现,非编码RNA(non-coding RNAs,ncRNAs)在心血管疾病相关的细胞死亡中发挥至关重要的作用. 此外,线粒体的动态平衡与3种类型的细胞死亡密切相关,非编码RNA能够通过靶向细胞死亡信号通路中的基因来调节心肌细胞中的线粒体分裂/融合平衡. 重点介绍了在应激状态下的心肌细胞中,关于细胞凋亡/自噬/坏死和ncRNAs之间复杂关系的最新研究进展,以及对心脏病治疗的潜在应用价值.

关键词: 心肌细胞死亡, 心脏疾病, 凋亡, 非编码RNA

Abstract:

Loss of functional cardiomyocytes is a major contributing factor to myocardial remodeling and heart diseases due to limited regenerative capacity of adult myocardium. Apoptosis, programmed necrosis, and autophagy contribute to loss of cardiac myocytes that control the balance of cardiac cell death and cell survival through multiple intricate signaling pathways. In recent years, non-coding RNAs (ncRNAs) have received much attention because of their roles in cell death of cardiovascular diseases, such as myocardial infarction, cardiac hypertrophy, and heart failure. In addition, based on the view that mitochondrial morphology is linked to three types of cell death, ncRNAs are able to regulate mitochondrial fission/fusion of cardiomyocytes by targeting genes involved in cell death pathways. This paper focuses on recent progress regarding the complex relationship between apoptosis/necrosis/autophagy and ncRNAs in the context of myocardial cell death in response to stress. This paper also provides insight into the treatment for heart diseases that will guide novel therapies in the future.

Key words: cardiomyocyte death, heart diseases, apoptosis, non-coding RNAs

中图分类号:

Q291

董妍涵, 王昆. 非编码RNA在调控心脏细胞死亡相关的心血管疾病中的作用[J]. 上海大学学报(自然科学版), 2019, 25(3): 389-398.

DONG Yanhan , WANG Kun . Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 389-398.

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非编码RNA在调控心脏细胞死亡相关的心血管疾病中的作用

Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases

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