ABCG1 基因表达调控在心血管疾病中的作用

doi:10.12066/j.issn.1007-2861.2133

上海大学学报(自然科学版) ›› 2019, Vol. 25 ›› Issue (3): 415-424.doi: 10.12066/j.issn.1007-2861.2133

所属专题：精准与转化医学

ABCG1 基因表达调控在心血管疾病中的作用

师莹^1,², 姚柳^2,^3,⁴, 艾玎^2,^3,⁴()

^1. 天津市胸科医院天津市心血管病研究所,天津 300222
^2. 天津医科大学免疫微环境与疾病教育部重点实验室, 天津 300070
^3. 天津医科大学天津市代谢病重点实验室, 天津 300070
^4. 天津医科大学生理学与病理生理学系, 天津 300070

收稿日期:2019-04-08 出版日期:2019-06-30 发布日期:2019-06-24
通讯作者: 艾玎 E-mail:dingai@tmu.edu.cn
作者简介:艾玎,教授,博士生导师,国家自然科学基金委优秀青年科学基金获得者,教育部长江学者奖励计划青年长江学者。天津医科大学生理学与病理生理学系教授, 博士生导师.2009 年毕业于北京大学医学部, 获生理学博士学位.2007─2008 年受国家留学基金委资助赴美国加州大学进行访问研究.2009─2013 年在美国哥伦比亚大学做博士后.2013 年起任天津医科大学生理学与病理生理学系教授.长期从事脂质代谢产物、途径及通路在炎症反应调节和心血管疾病中发病机制的研究.主要研究方向为雷帕霉素复合物 1(mTORC1), Hippo/YAP 及多不饱和脂肪酸代谢在心血管功能调控的分子机制及疾病中的作用. 从 2007 年至今,共发表研究论文和综述文章 36 篇,其中以第一作者或通信作者身份发表研究性论文 14 篇.近 5 年来围绕 mTORC1, Hippo/YAP 及多不饱和脂肪酸代谢产物在促进脂代谢紊乱及动脉粥样硬化机制方面进行深入研究, 以责任作者身份在 The Journal of Clinical Investigation, Circulation Research},Hepatology, British Journal of Pharmacology,FASEB Journal, Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 及 Diabetologia 等学术期刊发表研究性论文,并作为通信作者受邀撰写专业综述论文 2 篇 British Journal of Pharmacology, Journal of Diabetes).2013 年获得国家自然科学基金委优秀青年科学基金项目、2017 年度教育部长江学者奖励计划青年长江学者项目等支持,是多个心血管领域专业委员会成员,担任中国病理生理学会及中国生理学会青年委员.
基金资助:
国家自然科学基金青年科学基金资助项目(81700506)

Role of regulation of ABCG1 gene expression in cardiovascular diseases

SHI Ying^1,², YAO Liu^2,^3,⁴, AI Ding^2,^3,⁴()

^1. Tianjin Institute of Cardiovascular Disease, Tianjin Chest Hospital, Tianjin 300222, China
^2. Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin 300070, China
^3. Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University,Tianjin 300070, China
^4. Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China

Received:2019-04-08 Online:2019-06-30 Published:2019-06-24
Contact: Ding AI E-mail:dingai@tmu.edu.cn

摘要/Abstract

摘要：

胆固醇流出作为胆固醇逆向运输的第一步, 是维持细胞稳态的重要机制.三磷酸腺苷结合盒转运蛋白G1 (adenosine triphophate (ATP)-binding cassette (ABC) transporter G1, ABCG1) 能够促进细胞内胆固醇流出至胞外的高密度脂蛋白, 参与维持细胞胆固醇动态平衡, 在动脉粥样硬化、肥胖以及糖尿病等多种疾病中发挥重要作用.ABCG1 的基因表达受多重因素调控,如转录因子、蛋白修饰、DNA 甲基化及小分子核糖核酸的调控,进而影响多种疾病的发生发展.主要针对 ABCG1 及其表达调控在心血管疾病中的作用作一综述,以期为该领域的研究提供新的方向.

关键词: 三磷酸腺苷结合盒转运蛋白G1, 心血管疾病, 胆固醇, 基因表达

Abstract:

Cholesterol efflux, the first step in reverse cholesterol transport, is an important mechanism for maintaining cell homeostasis. Adenosine triphophate (ATP)-binding cassette (ABC) transporter G1 (ABCG1) maintains cellular cholesterol homeostasis by promoting intracellular cholesterol efflux to high density lipoprotein and it plays a crucial role in atherosclerosis, obesity and diabetes. The expression of ABCG1 is regulated by several factors, including transcript factor, protein modification, DNA methylation and microRNA, and subsequently it contributes to the development of several diseases. In this paper, the role of ABCG1 and its regulation in cardiovascular diseases have been reviewed, and it is hoped that exploration into this area will help bring about new ideas for the research in this field.

Key words: ATP-binding cassette transporter G1 (ABCG1), cardiovascular disease, cholesterol, gene expression

中图分类号:

R541

师莹, 姚柳, 艾玎. ABCG1 基因表达调控在心血管疾病中的作用[J]. 上海大学学报(自然科学版), 2019, 25(3): 415-424.

SHI Ying , YAO Liu , AI Ding . Role of regulation of ABCG1 gene expression in cardiovascular diseases[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 415-424.

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ABCG1 基因表达调控在心血管疾病中的作用

Role of regulation of ABCG1 gene expression in cardiovascular diseases

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