蛋白翻译后SUMO化修饰在动脉粥样硬化中的作用与机制

doi:10.12066/j.issn.1007-2861.2136

上海大学学报(自然科学版) ›› 2019, Vol. 25 ›› Issue (3): 406-414.doi: 10.12066/j.issn.1007-2861.2136

所属专题：精准与转化医学

蛋白翻译后SUMO化修饰在动脉粥样硬化中的作用与机制

祝昀辉, 周晓菲, 余路阳()

浙江大学生命科学学院, 杭州 310058

收稿日期:2019-04-10 出版日期:2019-06-30 发布日期:2019-06-24
通讯作者: 余路阳 E-mail:luyangyu@zju.edu.cn
作者简介:余路阳,教授,博士生导师,国家自然科学基金委优秀青年科学基金获得者,浙江省千人计划专家。
浙江大学生命科学学院副院长.国家自然科学基金委优秀青年科学基金获得者、浙江省千人计划专家,中国药理学会表观遗传药理学专业委员会常务委员、中国病理生理学会血管医学专业委员会委员、中国生理学会基质生物学专业委员会委员、中国生物化学与分子生物学会脂质与脂蛋白专业委员会委员、中国医药生物技术协会转化医学分会委员、``细胞治疗北京市工程实验室''专家委员会委员等.主要从事心脑血管疾病的疾病模型建立、分子病理和干细胞治疗研究.迄今发表SCI论文30余篇, 其中以第一或通信作者在Journal of the American College of Cardiology, Journal of Experimental Medicine, Nature Communications, Circulation Research, Science Signaling等杂志发表.获得美国研究病理协会ASIP优秀实验病理研究奖、美国心脏协会AHA科学家发展基金奖、中国心脏大会基础研究青年学者奖以及参与获得教育部高等学校科学研究优秀成果奖科学技术进步二等奖、中华医学会科技奖.
基金资助:
国家自然科学基金资助项目(91839104);国家自然科学基金资助项目(81770444);中央高校基本科研业务费专项资金资助项目(2018XZZX001-10)

Role and mechanism of post-translational SUMOylation in atherosclerosis

ZHU Yunhui, ZHOU Xiaofei, YU Luyang()

College of Life Sciences, Zhejiang University,Hangzhou 310058, China

Received:2019-04-10 Online:2019-06-30 Published:2019-06-24
Contact: Luyang YU E-mail:luyangyu@zju.edu.cn

摘要/Abstract

摘要：

动脉粥样硬化是过程复杂的慢性炎症性疾病,涉及内皮激活、内皮功能障碍和局部炎症反应等多个关键病理步骤.小分子类泛素修饰因子(small ubiquitin-like modifier, SUMO)化修饰是真核细胞中常见的较新发现的蛋白翻译后修饰,参与多种细胞进程生物学事件, 如DNA的转录活性细胞增殖分化、蛋白质的稳定性和定位细胞凋亡以及细胞信号转导等. 近期研究发现,SUMO化在动脉粥样硬化发生发展的多个环节中起到重要的调控作用.针对动脉粥样硬化上述几个过程中涉及的蛋白翻译后SUMO化修饰对病程发展的调控作用及其机制的研究现状作一综述.

关键词: SUMO化修饰, 动脉粥样硬化, 炎性反应

Abstract:

Atherosclerosis is a complex chronic inflammatory disease involving multiple key pathological steps such as endothelial activation, endothelial dysfunction, and local inflammatory response. SUMOylation is a newly discovered post-translational modification in eukaryotic cells and is involved in a variety of cellular biological events such as cell proliferation and differentiation, apoptosis and cell signaling. Recent studies have found that SUMOylation is closely related to the development of atherosclerosis. This paper reviews the research status of the post-translational SUMOylation involved in the process of atherosclerosis and its mechanism.

Key words: SUMOylation, atherosclerosis, immunity response

中图分类号:

R543.5

祝昀辉, 周晓菲, 余路阳. 蛋白翻译后SUMO化修饰在动脉粥样硬化中的作用与机制[J]. 上海大学学报(自然科学版), 2019, 25(3): 406-414.

ZHU Yunhui , ZHOU Xiaofei , YU Luyang . Role and mechanism of post-translational SUMOylation in atherosclerosis[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 406-414.

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蛋白翻译后SUMO化修饰在动脉粥样硬化中的作用与机制

Role and mechanism of post-translational SUMOylation in atherosclerosis

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