运动诱导生理性心肌肥厚的非编码RNA调节机制

doi:10.12066/j.issn.1007-2861.2140

上海大学学报(自然科学版) ›› 2019, Vol. 25 ›› Issue (3): 425-434.doi: 10.12066/j.issn.1007-2861.2140

所属专题：精准与转化医学

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运动诱导生理性心肌肥厚的非编码RNA调节机制

王天慧, 肖俊杰()

上海大学生命科学学院, 上海 200444

收稿日期:2019-05-21 出版日期:2019-06-30 发布日期:2019-06-24
通讯作者: 肖俊杰 E-mail:junjiexiao@shu.edu.cn
作者简介:肖俊杰,教授,国家自然科学基金委优秀青年科学基金获得者。
上海大学生命科学学院副院长, 上海大学心血管研究所所长,心脏再生与衰老实验室主任. 代表性论文发表在Nat Commun,Cell Metab, Circulation, Annu Rev Genomics 等杂志. 担任 J Cardiovasc Transl Res 杂志副主编,BMC Med,Cell Transplant, J ThoracDis 和 Biomed Environ Sci 杂志编委.担任上海大学学术委员会委员、中国康复医学会心血管专业委员会常务委员、中国生物物理学会代谢生物学分会理事、中国生理学会循环生理专业委员会委员、中国病理生理学会心血管专业委员会青年委员、国际心脏研究会 (ISHR) 中国分会青年委员、国际心脏研究会中国转化医学工作委员会委员、中国老年学会衰老与抗衰老科学委员会委员、上海市康复医学会心血管专业委员会委员、上海市生理学会理事、上海细胞生物学学会委员.目前正主持国家自然科学基金委优秀青年科学基金在内的 3 项国家自然基金项目、1 项上海市教委重大创新项目、1 项上海市科委国际合作项目,获得 2016 年度上海人才发展资金资助,是上海市青年岗位能手和宝钢优秀教师奖获得者. 主要研究领域:心力衰竭的综合干预和风险预警策略.
基金资助:
国家自然科学基金资助项目(81722008);国家自然科学基金资助项目(91639101);国家自然科学基金资助项目(81570362);上海市教委科研创新计划自然科学重大资助项目(2017-01-07-00-09-E00042);上海市科委部分地方院校能力建设资助项目(17010500100);上海市国际科技合作基金资助项目(18410722200)

Non-coding RNAs in exercise-induced cardiac hypertrophy

WANG Tianhui, XIAO Junjie()

School of Life Sciences, Shanghai University, Shanghai 200444, China

Received:2019-05-21 Online:2019-06-30 Published:2019-06-24
Contact: Junjie XIAO E-mail:junjiexiao@shu.edu.cn

摘要/Abstract

摘要：

大量研究表明运动训练对心脏具有保护作用. 运动可诱导生理性心肌肥厚,对于心力衰竭具有保护作用. 心肌肥厚可分为生理性和病理性心肌肥厚,后者可导致心脏功能受损、心力衰竭以及高死亡率. 近几十年来,非编码 RNA 包括微小 RNA (microRNA, miRNAs)、长链非编码 RNA (long noncodingRNA, lncRNAs) 和环状 RNA (circularRNA, circRNAs) 等,引起了研究者的极大关注,非编码 RNA 的失调被证实与多种心血管疾病密切相关. 综述了心肌肥厚,尤其是生理性心肌肥厚中 miRNAs,lncRNAs 和 circRNAs 的特征、功能和分子机制.同向调控这些运动影响的非编码 RNA 可以防治心力衰竭.

关键词: 非编码 RNA, 运动, 生理性心肌肥厚, 病理性心肌肥厚

Abstract:

Increasing evidence supports the protective role of exercise training in preventing cardiovascular diseases. Exercise induces physiological cardiac growth, and thus protects the heart against pathological remodeling and heart failure. Cardiac hypertrophy falls into two types, namely, the physiological cardiac hypertrophy and the pathological cardiac hypertrophy, and the latter can result in impaired cardiac functioning, heart failure and is predictive of a higher incidence of death due to cardiovascular diseases. Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have drawn significant attention over the last couple of decades, and their dysregulation is increasingly being linked to many cardiovascular diseases. In this paper, the profiling function, and molecular mechanism of miRNAs, lncRNAs, and circ- RNAs in cardiac hypertrophy, especially in physiological hypertrophy have been analyzed. Targeting these ncRNAs represents novel therapy for heart failure.

Key words: non-coding RNAs, exercise, physiological cardiac hypertrophy, pathological cardiac hypertrophy

中图分类号:

R541

王天慧, 肖俊杰. 运动诱导生理性心肌肥厚的非编码RNA调节机制[J]. 上海大学学报(自然科学版), 2019, 25(3): 425-434.

WANG Tianhui , XIAO Junjie . Non-coding RNAs in exercise-induced cardiac hypertrophy[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 425-434.

参考文献 52

[1]	Roth G A, Johnson C, Abajobir A , et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015[J]. J Am Coll Cardiol, 2017,70(1):1-25. doi: 10.1016/j.jacc.2017.04.052 pmid: 28527533
[2]	胡盛寿, 高润霖, 刘力生 , 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019,34(3):209-219.
[3]	Sharma S, Merghani A, Mont L . Exercise and the heart: the good, the bad, and the ugly[J]. European Heart Journal, 2015,36(23):1445-1453. doi: 10.1093/eurheartj/ehv090 pmid: 25839670
[4]	Gomes C P C, De Gonzalo-Calvo D, Toro R , et al. Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system[J]. Clinical Science, 2018,132(9):925-942. doi: 10.1042/CS20171463 pmid: 29780023
[5]	Raimondo D D, Miceli G, Musiari G , et al. New insights about the putative role of myokines in the context of cardiac rehabilitation and secondary cardiovascular prevention[J]. Ann Transl Med, 2017,5(15):300. doi: 10.21037/atm.2017.07.30 pmid: 28856140
[6]	Birney E, Stamatoyannopoulos J A, Dutta A , et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project[J]. Nature, 2007,447:799-816. doi: 10.1038/nature05874 pmid: 17571346
[7]	Zaratiegui M, Irvine D V, Martienssen R A . Noncoding RNAs and gene silencing[J]. Cell, 2007,128(4):763-776. doi: 10.1016/j.cell.2007.02.016 pmid: 17320512
[8]	Ottaviani L, Martins P A D C. Non-coding RNAs in cardiac hypertrophy[J]. The Journal of Physiology, 2017,595(12):4037-4050. doi: 10.1113/JP273129 pmid: 28233323
[9]	Bang C, Batkai S, Dangwal S , et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy[J]. Journal of Clinical Investigation, 2014,124(5):2136-2146. doi: 10.1172/JCI70577
[10]	Djebali S, Davis CA, Merkel A , et al. Landscape of transcription in human cells[J]. Nature, 2012,489:101-108. doi: 10.1038/nature11233
[11]	Eding J E C, Demkes C J, Lynch J M , et al. The efficacy of cardiac anti-miR-208a therapy is stress dependent[J]. Molecular Therapy, 2017,25(3):694-704. doi: 10.1016/j.ymthe.2017.01.012 pmid: 28202391
[12]	Anderson L, Oldridge N, Thompson D R , et al. Exercise-based cardiac rehabilitation for coronary heart disease: cochrane systematic review and Meta-analysis[J]. Journal of the American College of Cardiology, 2016,67(1):1-12. doi: 10.1016/j.jacc.2015.10.044 pmid: 26764059
[13]	Ellison G M, Waring C D, Vicinanza C , et al. Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms[J]. Heart, 2012,98(1):5-10. doi: 10.1136/heartjnl-2011-300639
[14]	Weiner R B, Baggish A L . Exercise-induced cardiac remodeling[J]. Progress in Cardiovascular Diseases, 2012,54(5):380-386. doi: 10.1016/j.pcad.2012.01.006
[15]	Van R E . The art of microRNA research[J]. Circulation Research, 2011,108(2):219-234. doi: 10.1161/CIRCRESAHA.110.227496
[16]	Farh K K, Grimson A, Jan C , et al. The widespread impact of mammalian microRNAs on mRNA repression and evolution[J]. Science, 2005,310(5755):1817-1821. doi: 10.1126/science.1121158 pmid: 16308420
[17]	Griffiths-Jones S, Saini H K, Van Dongen S , et al. MiRBase: tools for microRNA genomics[J]. Nucleic Acids Res, 2008,36:D154-D158. doi: 10.1093/nar/gkm952 pmid: 17991681
[18]	Wang K C, Chang H Y . Molecular mechanisms of long noncoding RNAs[J]. Molecular Cell, 2011,43(6):904-914. doi: 10.1016/j.molcel.2011.08.018
[19]	Wilusz J E, Jnbaptiste C K, Lu L Y , et al. A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails[J]. Genes & Development, 2012,26(21):2392-2407. doi: 10.1016/j.ijpddr.2019.11.001 pmid: 31794951
[20]	Schonrock N, Harvey R P, Mattick J S . Long noncoding RNAs in cardiac development and pathophysiology[J]. Circulation Research, 2012,111(10):1349-1362. doi: 10.1161/CIRCRESAHA.112.268953
[21]	Qu S, Yang X, Li X , et al. Circular RNA: a new star of noncoding RNAs[J]. Cancer Letters, 2015,365(2):141-148. doi: 10.1016/j.canlet.2015.06.003 pmid: 26052092
[22]	Hsiao K Y, Sun H S, Tsai S J . Circular RNA: new member of noncoding RNA with novel functions[J]. Experimental Biology & Medicine, 2017,242(11):1136-1141. doi: 10.1016/j.phytochem.2019.112214 pmid: 31794881
[23]	Tay Y, Rinn J, Pandolfi P P . The multilayered complexity of ceRNA crosstalk and competition[J]. Nature, 2014,505(7483):344-352. doi: 10.1038/nature12986
[24]	Du W W, Zhang C, Yang W , et al. Identifying and characterizing circRNA-protein interaction[J]. Theranostics, 2017,7(17):4183-4191. doi: 10.7150/thno.21299 pmid: 29158818
[25]	Li Z, Huang C, Bao C , et al. Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol, 2015,22(3):256-264. doi: 10.1038/nsmb.2959 pmid: 25664725
[26]	Ashwal-Fluss R, Meyer M, Pamudurti N R , et al. CircRNA biogenesis competes with pre-mRNA splicing[J]. Molecular Cell, 2014,56(1):55-66. doi: 10.1016/j.molcel.2014.08.019
[27]	Qu S, Zhong Y, Shang R , et al. The emerging landscape of circular RNA in life processes[J]. RNA Biology, 2016,14(8):1-8. doi: 10.1016/j.celrep.2019.02.078 pmid: 30893614
[28]	Ramasamy S, Velmurugan G, Shanmugha R K , et al. MiRNAs with apoptosis regulating potential are differentially expressed in chronic exercise-induced physiologically hypertrophied hearts[J]. PLoS One, 2015,10(3):e0121401. doi: 10.1371/journal.pone.0121401 pmid: 25793527
[29]	Fernandes T, Hashimoto N Y, Magalh$\tilde{a}$es F C, et al. Aerobic exercise training-induced left ventricular hypertrophy involves regulatory microRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7)[J]. Hypertension, 2011,58(2):182-189. doi: 10.1161/HYPERTENSIONAHA.110.168252
[30]	Car$\grave{e}$ A, Catalucci D, Felicetti F , et al. MicroRNA-133 controls cardiac hypertrophy[J]. Nature Medicine, 2007,13(5):613-618. doi: 10.1038/nm1582 pmid: 17468766
[31]	Ma Z, Qi J, Meng S , et al. Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway[J]. European Journal of Applied Physiology, 2013,113(10):2473-2486. doi: 10.1007/s00421-013-2685-9
[32]	Yang L, Li Y, Wang X , et al. Overexpression of miR-223 tips the balance of pro- and anti-hypertrophic signaling cascades toward physiologic cardiac hypertrophy[J]. Journal of Biological Chemistry, 2016,291:15700-15713. doi: 10.1074/jbc.M116.715805 pmid: 27226563
[33]	Wang L, Lv Y, Li G , et al. MicroRNAs in heart and circulation during physical exercise[J]. Journal of Sport and Health Science, 2018,7(4):433-441. doi: 10.1016/j.jshs.2018.09.008 pmid: 30450252
[34]	Soci U P, Fernandes T, Barauna V G , et al. Epigenetic control of exercise training-induced cardiac hypertrophy by miR-208[J]. Clinical Science, 2016,130(22):2005-2015. doi: 10.1042/CS20160480 pmid: 27503950
[35]	Soci U P, Fernandes T, Hashimoto N Y , et al. MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats[J]. Physiological Genomics, 2011,43(11):665-673. doi: 10.1152/physiolgenomics.00145.2010
[36]	Lin R C, Weeks K L, Gao X M , et al. PI3K (p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010,30(4):724-732. doi: 10.1161/ATVBAHA.109.201988 pmid: 20237330
[37]	Van Rooij E, Sutherland L B, Thatcher J E , et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis[J]. Proceedings of the National Academy of Sciences, 2008,105(35):13027-13032. doi: 10.1073/pnas.0805038105 pmid: 18723672
[38]	Da Silva N D, Fernandes T, Soci U P , et al. Swimming training in rats increases cardiac microRNA-126 expression and angiogenesis[J]. Med Sci Sports Exerc, 2012,44:1453-1462. doi: 10.1249/MSS.0b013e31824e8a36 pmid: 22330028
[39]	Liu X, Xiao J, Zhu H , et al. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling[J]. Cell Metabolism, 2015,21(4):584-595. doi: 10.1016/j.cmet.2015.02.014 pmid: 25863248
[40]	Shi J, Bei Y, Kong X , et al. MiR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury[J]. Theranostics, 2017,7(3):664-676. doi: 10.7150/thno.15162 pmid: 28255358
[41]	Zhao Y, Li H, Fang S , et al. NONCODE 2016: an informative and valuable data source of long non-coding RNAs[J]. Nucleic Acids Research, 2015,44(D1):D203-D208. doi: 10.1093/nar/gkv1252 pmid: 26586799
[42]	Sun L, Zhang Y, Zhang Y , et al. Expression profile of long non-coding RNAs in a mouse model of cardiac hypertrophy[J]. International Journal of Cardiology, 2014,177(1):73-75. doi: 10.1016/j.ijcard.2014.09.032 pmid: 25499344
[43]	Li X, Zhang L, Liang J . Unraveling the expression profiles of long noncoding RNAs in rat cardiac hypertrophy and functions of lncRNA BC088254 in cardiac hypertrophy induced by transverse aortic constriction[J]. Cardiology, 2016,134(2):84-98. doi: 10.1159/000443370 pmid: 26919297
[44]	Yang K C, Yamada K A, Patel A Y , et al. Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support[J]. Circulation, 2014,129(9):1009-1021. doi: 10.1161/CIRCULATIONAHA.113.003863
[45]	Han P, Li W, Lin C H , et al. A long noncoding RNA protects the heart from pathological hypertrophy[J]. Nature, 2014,514:102-106. doi: 10.1038/nature13596
[46]	Wang Z, Zhang X J, Ji Y X , et al. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy[J]. Nature Medicine, 2016,22:1131-1139. doi: 10.1038/nm.4179 pmid: 27618650
[47]	Lv L, Li T, Li X , et al. LncRNA Plscr4 controls cardiac hypertrophy by regulating miR-214[J]. Mol Ther Nucleic Acids, 2017,10:387-397. doi: 10.1016/j.omtn.2017.12.018 pmid: 29499950
[48]	Li Y, Liang Y, Zhu Y , et al. Noncoding RNAs in cardiac hypertrophy[J]. Journal of Cardiovascular Translational Research, 2018,11:439-449. doi: 10.1007/s12265-018-9797-x pmid: 30171598
[49]	Wang L, Meng X, Li G , et al. Circular RNAs in cardiovascular diseases [J]. [J]. Adv Exp Med Biol, 2018,1087:191-204. doi: 10.1007/978-981-13-1426-1_15 pmid: 30259367
[50]	Zhou Q, Zhang Z, Bei Y , et al. Circular RNAs as novel biomarkers for cardiovascular diseases[J]. Adv Exp Med Biol, 2018,1087:159-170. doi: 10.1007/978-981-13-1426-1_13 pmid: 30259365
[51]	Werfel S, Nothjunge S, Schwarzmayr T , et al. Characterization of circular RNAs in human, mouse and rat hearts[J]. J Mol Cell Cardiol, 2016,98:103-107. doi: 10.1016/j.yjmcc.2016.07.007 pmid: 27476877
[52]	Tan W L W, Lim B T S, Anene-Nzelu C G O , et al. A landscape of circular RNA expression in the human heart[J]. Cardiovasc Res, 2017,113:298-309. doi: 10.1093/cvr/cvw250 pmid: 28082450

运动诱导生理性心肌肥厚的非编码RNA调节机制

Non-coding RNAs in exercise-induced cardiac hypertrophy

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