[1] Benjamin E J, Blaha M J, Chiuve S E, et al. Heart disease and stroke statistics-2017 update: a report from the american heart association [J]. Circulation, 2017, 135(10): e634-e1003.

[2] Catucci M, Prete F, Bosticardo M, et al. Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome [J]. Gene Therapy, 2012, 19(12): 1150-1158.

[3] Tilemann L, Ishikawa K, Weber T, et al. Gene therapy for heart failure [J]. Circulation Research, 2012, 110(5): 777-793.

[4] Su C H, Wu Y J, Wang H H, et al. Nonviral gene therapy targeting cardiovascular system[J]. American Journal of Physiology Heart & Circulatory Physiology, 2012, 303(6): 629-638.

[5] Ferrara K, Pollard R, Borden M. Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery [J]. Annual Review of Biomedical Engineering, 2007, 9: 415-447.

[6] Bei Y, Xu T, L¨U D, et al. Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury [J]. Basic Research in Cardiology, 2017, 112(4): 38.

[7] Eulalio A, Mano M, dal Ferro M, et al. Functional screening identifies miRNAs inducing cardiac regeneration [J]. Nature, 2012, 492(7429): 376-381.

[8] Santiagortiz J L, Schaffer D V. Adeno-associated virus (AAV) vectors in cancer gene therapy [J]. Journal of Controlled Release, 2016, 240: 287-301.

[9] Prasad K M, Xu Y, Yang Z, et al. Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution [J]. Gene Therapy,

2011, 18(1): 43-52.

[10] Pleger S T, Shan C, Ksienzyk J, et al. Cardiac AAV9-S100A1 gene therapy rescues postischemic heart failure in a preclinical large animal model [J]. Science Translational Medicine, 2011, 3(92): 92ra64.

[11] Bey K, Ciron C, Dubreil L, et al. Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders [J]. Gene Therapy, 2017,

24(5): 325-332.

[12] Martini S V, Silva A L, Ferreira D, et al. Tyrosine mutation in AAV9 capsid improves gene transfer to the mouse Lung [J]. Cellular Physiology and Biochemistry, 2016, 39(2): 544-553.

[13] Chen B D, He C H, Chen X C, et al. Targeting transgene to the heart and liver with AAV9 by different promoters [J]. Clininal and Experimental Pharmacology and Physiology, 2015, 42(10): 1108-1117.