非编码RNA在调控心脏细胞死亡相关的心血管疾病中的作用

doi:10.12066/j.issn.1007-2861.2137

Abstract

Abstract:

Loss of functional cardiomyocytes is a major contributing factor to myocardial remodeling and heart diseases due to limited regenerative capacity of adult myocardium. Apoptosis, programmed necrosis, and autophagy contribute to loss of cardiac myocytes that control the balance of cardiac cell death and cell survival through multiple intricate signaling pathways. In recent years, non-coding RNAs (ncRNAs) have received much attention because of their roles in cell death of cardiovascular diseases, such as myocardial infarction, cardiac hypertrophy, and heart failure. In addition, based on the view that mitochondrial morphology is linked to three types of cell death, ncRNAs are able to regulate mitochondrial fission/fusion of cardiomyocytes by targeting genes involved in cell death pathways. This paper focuses on recent progress regarding the complex relationship between apoptosis/necrosis/autophagy and ncRNAs in the context of myocardial cell death in response to stress. This paper also provides insight into the treatment for heart diseases that will guide novel therapies in the future.

Key words: cardiomyocyte death, heart diseases, apoptosis, non-coding RNAs

CLC Number:

Q291

DONG Yanhan , WANG Kun . Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 389-398.

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Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases

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