非编码RNA调控心脏重构与再生

doi:10.3969/j.issn.1007-2861.2016.03.021

Abstract

Abstract:

Recently, more and more evidences indicate that a large number of non-coding RNAs (ncRNAs) are involved in gene expression, physiological and pathological regulation, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Cardiac remodeling and regeneration are key to cardiovascular biology and diseases. Regulation of gene expression during cardiac remodeling and regeneration is complicated, involving epigenetic, transcriptional, post-transcriptional and translational regulation. In the past decade, miRNAs have drawn much attention for their impact on cardiovascular diseases and regeneration. miRNAs negatively regulate the expression of the target genes through post-transcriptional regulation. Recent research uncovered that lncRNAs play an important role in cardiac development and diseases, involving epigenetic, transcriptional and post-transcriptional regulation, making lncRNAs become another group of key regulatory non-coding RNAs. This paper summarizes the recent progress in the study of non-coding RNAs in cardiac remodeling and cardiac regeneration.

Key words: cardiac regeneration, cardiac remodeling , long non-coding RNAs (lncRNAs) , microRNAs (miRNAs)

GAO Feng1,2, CHEN Jinghai1,2. Non-coding RNAs mediate cardiac remodeling and regeneration[J]. Journal of Shanghai University（Natural Science Edition）, 2016, 22(3): 302-309.

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Non-coding RNAs mediate cardiac remodeling and regeneration

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