干细胞与心肌再生

doi:10.3969/j.issn.1007-2861.2016.03.016

Abstract

Abstract:

Human myocardium has poor regenerative power, and significant myocardial injury results in irreversible damage, remodeling, and dysfunction. Stem cells enable promising regenerative strategies for cardiovascular diseases. The search for suitable stem cell phenotypes that will improve myocardial regenerative ability needs better understanding of the molecular mechanisms of repair and regeneration. Previous reports have suggested that several stem phenotypes regulate myocardial regeneration in vitro and in vivo. This review describes the therapeutic potential of mesenchymal stem cell (MSC) therapy in terms of angiogenic and regenerative capacity after myocardial infarction. In addition, the effect of cardiac side population cells (CSPs) and the differentiation of induced pluripotent stem cells (iPSCs) in cardiac regeneration are discussed. The review provides recent data and helps broaden therapeutic potential and clinical impact of stem cell therapy.

Key words: cardiac regeneration , cardiac side population cells (CSPs) , induced pluripotent stem cells (iPSCs), mesenchymal stem cell (MSC) , stem cell

GONG Hui, CHEN Zhidan, ZOU Yunzeng. Stem cells and cardiac regeneration[J]. Journal of Shanghai University（Natural Science Edition）, 2016, 22(3): 280-284.

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Stem cells and cardiac regeneration

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