血管衰老中的表观遗传调控

doi:10.12066/j.issn.1007-2861.2138

Abstract

Abstract:

Vascular aging refers to the structural and functional changes of aorta during the aging process. It is characterized by vascular remodeling, vascular dyshomeostasis and vascular cell senescence. Epigenetic regulation can influence gene expression without changing the DNA sequence and it mainly includes DNA methylation, histone modifications, and RNA-based gene regulation. Current researches demonstrate that epigenetic regulation plays important roles in vascular aging and age-related diseases, and drugs targeting epigenetic regulation are expected to be new treatments for age-related diseases.

Key words: vascular aging, epigenetic regulation, DNA methylation, histone modification, non-coding RNAs, Senescaging

CLC Number:

DING Yangnan , LÜ Shuangjie , CHEN Houzao , LIU Depei . Epigenetic regulation in vascular aging[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 381-388.

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Epigenetic regulation in vascular aging

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