运动诱导生理性心肌肥厚的非编码RNA调节机制

doi:10.12066/j.issn.1007-2861.2140

Abstract

Abstract:

Increasing evidence supports the protective role of exercise training in preventing cardiovascular diseases. Exercise induces physiological cardiac growth, and thus protects the heart against pathological remodeling and heart failure. Cardiac hypertrophy falls into two types, namely, the physiological cardiac hypertrophy and the pathological cardiac hypertrophy, and the latter can result in impaired cardiac functioning, heart failure and is predictive of a higher incidence of death due to cardiovascular diseases. Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have drawn significant attention over the last couple of decades, and their dysregulation is increasingly being linked to many cardiovascular diseases. In this paper, the profiling function, and molecular mechanism of miRNAs, lncRNAs, and circ- RNAs in cardiac hypertrophy, especially in physiological hypertrophy have been analyzed. Targeting these ncRNAs represents novel therapy for heart failure.

Key words: non-coding RNAs, exercise, physiological cardiac hypertrophy, pathological cardiac hypertrophy

CLC Number:

R541

WANG Tianhui , XIAO Junjie . Non-coding RNAs in exercise-induced cardiac hypertrophy[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 425-434.

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Non-coding RNAs in exercise-induced cardiac hypertrophy

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