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Journal of Shanghai University（Natural Science Edition） ›› 2016, Vol. 22 ›› Issue (3): 371-375.doi: 10.3969/j.issn.1007-2861.2016.03.015

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Influence of alprostadil on preventing left ventricular remodeling after acute myocardial infarction

ZHAN Li1,2, XU Jiahong1   

  1. 1. Department of Cardiology, Tongji Hospital Affiliated to Medical College of Tongji University, Shanghai 200065, China;
    2. Department of ECG, Zhenhai District People’s Hospital, Ningbo 315202, Zhejiang, China
  • Received:2016-04-19 Online:2016-06-30 Published:2016-06-30

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Abstract:

To investigate the clinic effect of alprostadil on preventing left ventricular remodeling after acute myocardial infarction (AMI). A total of 73 cases of AMI were randomly divided into two groups: basic treatment group and alprostadil treatment group. Both groups were given basic treatments such as rest, oxygen inhalation, dual antiplatelet therapy. Alprostadil was intravenously injected in the alprostadil treatment group, 10 μg once a day for 7 days. Left ventricular end-diastolic dimension (LVDd), left ventricular end-systolic dimension (LVDs), interventricular septal thickness (IVST), left ventricle posterior wall end-diastolic (LVPWd), ejection fraction (EF) and E/A ratio were measured by echocardiography on the 3rd and the 28th days after treatment. Compared to the 3rd day after treatment, LVDd, LVDs, IVST, LVPWd, EF, E/A ratio in the basic treatment group had no significant changes on the 28th day after treatment. LVDd, LVDs, E/A ratio in the alprostadil treatment group on the 28th day after treatment were significantly reduced in comparison with the 3rd day after treatment (P <0.05) while IVST and LVPWd showed no significant changes. Alprostadil improves cardiac function after acute myocardial infarction in short term, but has no influence on preventing left ventricular remodeling.

Key words:  acute myocardial infarction ,  left ventricular remodeling, alprostadil