Journal of Shanghai University(Natural Science Edition) ›› 2016, Vol. 22 ›› Issue (3): 366-370.doi: 10.3969/j.issn.1007-2861.2016.03.019

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Circulating miR-21-3p as biomarkers for sepsis-induced cardiomyopathy

LIU Hui, WANG Hui, SHI Jing, KONG Xiangqing   

  1. Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2016-04-22 Online:2016-06-30 Published:2016-06-30

Abstract:

Recently, microRNAs(miRNAs) are found to be abundantly present in body fluids including plasma and serum, and called circulating miRNAs. Increasing evidences suggest that circulating miRNAs may be useful as stable blood-based biomarkers in sepsis. Serum miR-21-3p is significantly increased in septic patients compared with healthy controls. Receiver operating characteristic (ROC) curve analyses suggest that these plasma miR-21-3p may be useful biomarkers for discriminating patients with sepsis-induced cardiomyopathy (SIC) from healthy controls. miR-21-3p yields the ROC area under the curve
(AUC) of 0.949. Further analyses indicate that the expression level of miR-21-3p is correlated with the brain natriuretic peptide (BNP) (r = 0.968, P < 0.001) and cardiac troponin T (cTNT) level (r = 0.257, P = 0.002). Serum miR-21-3p may serve as new biomarkers for sepsis with high specificity and sensitivity.

Key words:  circulating miRNAs,  miR-21-3p , sepsis-induced cardiomyopathy (SIC)