Journal of Shanghai University(Natural Science Edition) ›› 2016, Vol. 22 ›› Issue (3): 318-325.doi: 10.3969/j.issn.1007-2861.2016.03.012

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Application of sonosensitizers derived from Chinese herb products in sonodynamic therapy for atherosclerosis treatment

KOU Jiayuan1, JIANG Yueqing1, TIAN Ye1,2, YANG Liming1   

  1. 1. Department of Pathophysiology, Harbin Medical University, Harbin 150081, China;
    2. Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China
  • Received:2016-04-19 Online:2016-06-30 Published:2016-06-30

Abstract:

At present, morbidity of cardiovascular disease induced by atherosclerosis (AS) is becoming higher. Besides expensive intervention and bypass surgery, it is extremely urgent to look for a popular and effective method for the treatment of AS. Sonodynamic therapy (SDT) is a non-invasive targeting therapy, and is promising for AS treatment based on the SDT-related research. Sonosensitizer, an application of SDT, is an entry points of the SDT investigation. Therefore, different sonodynamic effects with different sonosensitizers are investigated by researchers in AS treatment. In recent years, it is found that sonosensitizers derived from Chinese herb products play an important role in SDT, exerting potent sonodynamic effects for AS treatment. This review briefly summarizes the action of SDT and relevant development of SDT with emodin, curcumin, hypericin and its derived derivatives as sonosensitizers for AS treatment.

Key words:  atherosclerosis,  Chinese herb product ,  sonosensitizer , sonodynamic therapy