Journal of Shanghai University(Natural Science Edition) ›› 2016, Vol. 22 ›› Issue (3): 326-330.doi: 10.3969/j.issn.1007-2861.2016.03.014

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Advances of transcription factor Bach1 in cardiovascular diseases

JIA Mengping, GUO Jieyu, MENG Dan   

  1. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
  • Received:2016-04-19 Online:2016-06-30 Published:2016-06-30

Abstract:

BTB and CNC homology 1 (Bach1) is a transcription factor widely existing in most tissues of mammals. Bach1 negatively regulates various antioxidant gene such as heme oxygenase-1 (HO-1), involving oxidative stress. Knockout of Bach1 has a protective effect on myocardial ischemia reperfusion injury. Recent research found that Bach1 inhibits the Wnt/b-catenin signaling pathway and angiogenesis in hindlimb ischemia of mice. This paper focuses on the research of Bach1 in cardiovascular diseases.

Key words:  angiogenesis ,  cardiovascular disease ,  Wnt signal, Bach1