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Journal of Shanghai University（Natural Science Edition） ›› 2023, Vol. 29 ›› Issue (2): 211-.doi: 10.12066/j.issn.1007-2861.2457

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Research progress of non-coding RNAs in liver cancer

YANG Qianqian1, TIAN Hui2, WANG Guangzhi3, MA Zhongliang1   

  1. 1. Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China; 2. Zhongshan Hospital, Fudan University, Shanghai 200032, China; 3. A±liated Hospital of Weifang Medical University, Weifang 261053, Shandong, China
  • Received:2022-09-17 Online:2023-04-30 Published:2023-04-30

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Abstract: Liver cancer is the leading global lethal malignancy. Hypoxia in the tumor microenvironment is a hallmark of the tumor microenvironment, and hypoxia-inducible factor-1a is the most important transcriptional regulator in response to hypoxia. Non- coding RNA (ncRNA) play a crucial role in regulating the pathogenesis and progression of hepatocellular carcinoma (HCC). This review comprehensively summarizes the pathological roles of ncRNA in hepatocarcinogenesis, epithelial-mesenchymal transition, and angiogen- esis under hypoxic environments, and discusses the potential applications of ncRNA as diagnostic tools and therapeutic targets for human HCC.

Key words: HIF-1a, non-coding RNA, liver cancer, tumor microenvironment

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