1-氯-3-丁烯-2-醇对人胚肝 L02 细胞中内源性 H$_{\textbf{2}}$S 的抑制效应

doi:10.12066/j.issn.1007-2861.1825

Abstract

Abstract:

1-chloro-2-hydroxy-3-butene (CHB) is a metabolite of 1,3-butadiene, an environmental pollutant. CHB is cytotoxic, genotoxic, and mutagenic. H$_2$S is the third gasotransmitter following NO and CO, and is involved in a variety of physiological activities. Abnormal metabolism of H$_2$S is associated with many diseases. In the present study, the effect of CHB on the concentrations of endogenous H$_2$S in human hepatocyte L02 cells was investigated. It was observed that CHB could cause significant decreases in the concentrations of endogenous H$_2$S in the cells and the effect depended on CHB concentration. Thus, inhibition of endogenous H$_2$S production in cells by CHB may be a mechanism for toxicity of CHB, which can contribute to a better understanding of toxicity of 1,3-butadiene.

Key words: 1-chloro-2-hydroxy-3-butene (CHB), H$_2$S, 1,3-butadiene, toxicity

CLC Number:

R994.6

ZHANG Fang, ZHANG Xinyu. Inhibition of endogenous H$_\textbf{2}$S concentrations in human hepatocyte L02 cells by 1-chloro-2-hydroxy-3-butene[J]. Journal of Shanghai University（Natural Science Edition）, 2018, 24(5): 800-806.

Figures/Tables 6

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References 15

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Inhibition of endogenous H$_\textbf{2}$S concentrations in human hepatocyte L02 cells by 1-chloro-2-hydroxy-3-butene

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