上海大学学报(自然科学版) ›› 2022, Vol. 28 ›› Issue (5): 821-830.doi: 10.12066/j.issn.1007-2861.2441
收稿日期:
2022-08-08
出版日期:
2022-10-30
发布日期:
2022-11-12
通讯作者:
肖俊杰
E-mail:junjiexiao@shu.edu.cn
作者简介:
肖俊杰(1983—), 男, 教授, 博士生导师, 博士, 研究方向为运动诱导的生理性心肌肥大. E-mail: junjiexiao@shu.edu.cn基金资助:
XIE Jinxin1, YANG Zijiang1, WANG Hongyun1, XIAO Junjie1,2()
Received:
2022-08-08
Online:
2022-10-30
Published:
2022-11-12
Contact:
XIAO Junjie
E-mail:junjiexiao@shu.edu.cn
摘要:
PIWI-interacting RNA(piRNA)是一类最初从生殖细胞中发现的长约 30 nt 的新型内源性非编码 RNA, 能够与 PIWI 蛋白家族成员结合抑制转座子, 保持种系基因组完整性. 随着研究的不断深入, piRNA 被证实在生殖细胞以外的其他组织细胞中亦可表达, 并且在众多的生理病理过程中发挥着重要的调节作用. 心血管疾病(cardiovascular disease, CVD)是引发全球人口死亡的首要原因. 基于 piRNA 的生物发生过程深入讨论了其在不同心血管疾病中的作用及潜在机制, 归纳了可用于防治及诊断心血管疾病的 piRNA 发明专利, 以期丰富 piRNA 的分子生物学理论, 并为防治心血管疾病提供新靶点和潜在策略.
中图分类号:
谢金鑫, 杨子江, 王红云, 肖俊杰. piRNA 调节心血管疾病的分子机制进展[J]. 上海大学学报(自然科学版), 2022, 28(5): 821-830.
XIE Jinxin, YANG Zijiang, WANG Hongyun, XIAO Junjie. Advances in the mechanism of piRNA regulating cardiovascular disease[J]. Journal of Shanghai University(Natural Science Edition), 2022, 28(5): 821-830.
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