上海大学学报(自然科学版) ›› 2010, Vol. 16 ›› Issue (1): 68-74.

• 数理化科学 • 上一篇    下一篇

细胞内圆柱形空间钙波的Fire-Diffuse-Fire模型

程玉1,施小民2,余宏旺1,郑毓蕃1,3   

  1. (1.上海大学 理学院,上海 200444; 2.上海大学 系统科学研究所,上海 200444; 3.华东师范大学 数学系,上海 200062)
  • 收稿日期:2008-05-29 出版日期:2010-02-28 发布日期:2010-02-28
  • 通讯作者: 郑毓蕃(1941~),男,教授,博士生导师,研究方向为系统科学. E-mail:yfzheng@staff.shu.edu.cn

Fire-Diffuse-Fire Calcium Waves in Cylindrical Intracellular Spaces

CHENG Yu1,SHI Xiao-min2,YU Hong-wang1,ZHENG Yu-fan1,3   

  1. (1. College of Sciences, Shanghai University, Shanghai 200444, China; 2. Institute of Systems Science, Shanghai University, Shanghai 200444, China; 3. Department of Mathematics, East China Normal University, Shanghai 200062, China)
  • Received:2008-05-29 Online:2010-02-28 Published:2010-02-28

摘要:

考察Fire-Diffuse-Fire模型在圆柱区域内钙波的传播情况.通过求解扩散方程,得到了圆柱区域内Ca2+浓度的解析表达式.分析证明了钙波的存在性、稳定性依赖于半径和Ca2+泵率,产生钙释放的阈值在有限区间内随半径增大而增大.此结果有助于了解细胞内的内质网以及Ca2+泵在细胞Ca2+动力学上的作用.

关键词: Fire-Diffuse-Fire模型;钙波;钙释放

Abstract:

Propagation of firediffusefire Ca2+ waves through a cylindric domain is considered. Ca2+ concentration is an analytic solution derived from the diffusion equation in the domain. Existence and stability are shown to be dependent on the radius and the Ca2+ pump rate. It is also shown that the threshold of fire increase as radius increasing in finite interval. The results provides better understanding about the roles of endoplasmic and Ca2+ pumps in the intracellular Ca2+ dynamics of cells. 

Key words:  fire-diffuse-fire model; Ca2+ waves; calcium release

中图分类号: