Abstract:

HSPC300/hHBRK1 protein involved in cell movement and material transport is a kind of human homologous proteins. Myosin Ⅵ protein is a member of the myosin family. It is possible that HSPC300/hHBRK1 protein andmyosin Ⅵ protein react for the reason that they are present in the cytoplasm of cells and they are both involved inintracellular transport of the material. To lay a foundation for further experiments, we predict the area of interactionunder the structural point by computer simulation of proteinprotein interactions, and find the related residues that may become the sites of amino acid interaction: PHE43, LYS105, THR676 and LEU40.

Key words: HSPC300/hHBRK1; myosin Ⅵ; structure prediction; docking