中文

Journal of Shanghai University（Natural Science Edition） ›› 2016, Vol. 22 ›› Issue (3): 376-380.doi: 10.3969/j.issn.1007-2861.2016.03.020

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Clinic significance of D-dimer in short-term prognosis of patients with acute heart failure

ZHANG Jialiang, GAO Rongrong, LI Xinli, WANG Hui   

  1. Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2016-04-22 Online:2016-06-30 Published:2016-06-30

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Abstract:

This paper investigates the clinic significance of D-dimer in short-term prognosis of patients with acute heart failure (AHF). A total of 206 patients with AHF were enrolled and followed up for 3 months. Baseline level of complete blood count, complete biochemistry, D-dimer and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured at admission or in the following morning. Primary endpoints of the study were cardiovascular (CV) events, defined as cardiac death and/or readmission for AHF. D-dimer and NT-proBNP were significantly higher in the patients who had a CV events in a 90-day period (P < 0.001). The analysis results of the receiver operating characteristic (ROC) curves showed that the area under the curves (AUCs) of NT-proBNP, and D-dimer for predicting CV events within 90 days were 0.806 and 0.887. Kaplan-Meier survival curves for the 90-day CV events showed that patients with a D-dimer level > 1.1 mg/dL and NT-proBNP level > 2 262.0 pg/mL were at high risk (P < 0.001) for short-term outcomes of AHF. D-dimer can be used as a new biomarker to enhance the value in early predicting cardiovascular events of AHF when combined with NT-proBNP.

Key words:  D-dimer ,  prognosis, acute heart failure (AHF)