Journal of Shanghai University(Natural Science Edition) ›› 2016, Vol. 22 ›› Issue (5): 552-559.doi: 10.3969/j.issn.1007-2861.2016.01.017

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Cell reprogramming based on hierarchical networks and feedback mechanism

LIU Shijin, LIU Yanwei, WANG Ruiqi   

  1. College of Sciences, Shanghai University, Shanghai 200444, China
  • Received:2016-02-23 Online:2016-10-31 Published:2016-10-31

Abstract:

The process that pluripotent cells differentiate and finally commit to certain cell lineages originates from stem cells. It is performed with a series of cellfate decisions driven by pluripotent progenitors. Reprogramming of pluripotent cells can occur in this process. Focusing on the cell differentiation and presenting a hierarchical network with double negative feedbacks, the reprogramming strategy in the pathways of cell differentiation can be induced by integrated influence of a hierarchical network and the feedback regulatory mechanisms.

Key words: feedback regulatory , hierarchical network ,  bifurcation analysis, cell reprogramming