Journal of Shanghai University(Natural Science Edition) ›› 2012, Vol. 18 ›› Issue (4): 425-429.doi: 10.3969/j.issn.1007-2861.2012.04.018
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ZHANG Jia-jun,LIAO Xian-yan,WENG Xin-chu
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Abstract: Effects of the compound of Ganoderma lucidum and Astragalus extracts on immunity and tumor of mice treated by cyclophosphamide (CTX) were investigated. The mice were given both compounds of Ganoderma lucidum and Astragalus extracts by gavage and CTX by peritoneal injection for two weeks after the mouse model bearing S180 tumor were produced. Then the antitumor effect, the thymus index, spleen index and the amount of white blood cells (WBCs) and red blood cells (RBCs) were observed and determined. Compared with the CTX group, the middle and high dose group of Ganoderma lucidum and Astragalus extracts significantly enhanced the effect of CTX on inhibiting the growth of S180 tumor (P<0.01), and prominently relieve thymic atrophy (P<0.01) and leucopenia (P<0.05, P<0.01) caused by CTX in mice. The compound of Ganoderma lucidum and Astragalus extracts showed synergy and attenuation of CTX in tumor therapy. Its efficacy was equivalent to that of single folium Ganoderma lucidum extract, which largely reduced the cost of single folium Ganoderma lucidum extract with a great economical value.
Key words: Astragalus, Ganoderma lucidum, antitumor, immunity
CLC Number:
R 285.5
ZHANG Jia-jun,LIAO Xian-yan,WENG Xin-chu. Efficacy of Compound of Ganoderma lucidum and AstragalusExtracts on TumorBearing Mice Treated by Cyclophosphamide[J]. Journal of Shanghai University(Natural Science Edition), 2012, 18(4): 425-429.
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URL: https://www.journal.shu.edu.cn/EN/10.3969/j.issn.1007-2861.2012.04.018
https://www.journal.shu.edu.cn/EN/Y2012/V18/I4/425