ABCG1 基因表达调控在心血管疾病中的作用

doi:10.12066/j.issn.1007-2861.2133

Abstract

Abstract:

Cholesterol efflux, the first step in reverse cholesterol transport, is an important mechanism for maintaining cell homeostasis. Adenosine triphophate (ATP)-binding cassette (ABC) transporter G1 (ABCG1) maintains cellular cholesterol homeostasis by promoting intracellular cholesterol efflux to high density lipoprotein and it plays a crucial role in atherosclerosis, obesity and diabetes. The expression of ABCG1 is regulated by several factors, including transcript factor, protein modification, DNA methylation and microRNA, and subsequently it contributes to the development of several diseases. In this paper, the role of ABCG1 and its regulation in cardiovascular diseases have been reviewed, and it is hoped that exploration into this area will help bring about new ideas for the research in this field.

Key words: ATP-binding cassette transporter G1 (ABCG1), cardiovascular disease, cholesterol, gene expression

CLC Number:

R541

SHI Ying , YAO Liu , AI Ding . Role of regulation of ABCG1 gene expression in cardiovascular diseases[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 415-424.

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Role of regulation of ABCG1 gene expression in cardiovascular diseases

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