蛋白翻译后SUMO化修饰在动脉粥样硬化中的作用与机制

doi:10.12066/j.issn.1007-2861.2136

Abstract

Abstract:

Atherosclerosis is a complex chronic inflammatory disease involving multiple key pathological steps such as endothelial activation, endothelial dysfunction, and local inflammatory response. SUMOylation is a newly discovered post-translational modification in eukaryotic cells and is involved in a variety of cellular biological events such as cell proliferation and differentiation, apoptosis and cell signaling. Recent studies have found that SUMOylation is closely related to the development of atherosclerosis. This paper reviews the research status of the post-translational SUMOylation involved in the process of atherosclerosis and its mechanism.

Key words: SUMOylation, atherosclerosis, immunity response

CLC Number:

R543.5

ZHU Yunhui , ZHOU Xiaofei , YU Luyang . Role and mechanism of post-translational SUMOylation in atherosclerosis[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(3): 406-414.

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Role and mechanism of post-translational SUMOylation in atherosclerosis

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