Journal of Shanghai University(Natural Science Edition) ›› 2017, Vol. 23 ›› Issue (3): 395-401.doi: 10.12066/j.issn.1007-2861.1886

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Relationship between galectin-3 and macrophage in inflammation reactions

LIU Zhongni, YANG Liming   

  1. Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China
  • Received:2016-12-20 Online:2017-06-30 Published:2017-06-30

Abstract:

Galectin-3 (Gal-3) is an approximately 30 kDa and highly conserved β-galactose distributed in a wide range of tissues and microenvironments. Its specific carbohydraterecognition domain and evolutionary conserved N-terminal domain of Gal-3 make it more flexible and multifunctional as a mediator affecting inflammation. Macrophage plays an important role in inflammatory reactions as a major immunocyte. This review focuses on the relationship between Gal-3 and macrophage in inflammatory reactions.

Key words: inflammation, macrophage, Galectin-3 (Gal-3)