水环境中双酚A污染及其对鱼类的毒性研究进展

摘要/Abstract

摘要： 双酚A(bisphenol A, BPA) 是公认的环境内分泌干扰物, 广泛存在于水环境中, 并对水生态系统的安全造成潜在威胁. 结合BPA 污染和毒理学的相关研究成果, 综述了BPA 在不同水体中的污染现状, 及其对鱼类的内分泌干扰作用、生殖毒性、免疫毒性和发育神经毒性. 在此基础上, 进一步指出了研究BPA 的重要性和今后的研究
方向.

关键词: 毒理学, 免疫毒性, 内分泌干扰, 神经毒性, 双酚A

Abstract: Bisphenol A (BPA) is a well-known endocrine-disrupting chemical present in aquatic environments, and has a potential threat on the aquatic ecosystem safety. Based on the studies, this paper reviews the literature concerning contamination status of BPA in various water bodies and its endocrine-disruptive, reproductive,
immunological and neurotoxic effects on fish, shows the importance of the BPA study and suggests directions of the future research.

Key words: bispehnol A (BPA), endocrine disruption, immunotoxicity, neurotoxicity, toxicology

中图分类号:

许海1,2, 杨明1, 吴明红1. 水环境中双酚A污染及其对鱼类的毒性研究进展[J]. 上海大学学报(自然科学版), 2013, 19(4): 429-436.

Hai1,2, YANG Ming1, WU Ming-hong1. Bisphenol A in the Aquatic Environment and Its Toxic Effects on FishXU[J]. Journal of Shanghai University（Natural Science Edition）, 2013, 19(4): 429-436.

参考文献

[1] Burridge E. Chemical profile: bisphenol A [N/OL].

[2013-05-15]. http://www. icis. com/Articles/ 2008/

10/13/9162868/Chemical-profile-bisphenol-A.html.

[2] 肖云波, 于海琴. 双酚A在环境中迁移转化的研究进

展[J]. 山西建筑, 2007, 33(6): 180-182.

[3] 张想竹, 侯绍刚, 吴明书. 双酚A 的环境行为研究进

展[J]. 安阳工学院学报, 2006, 20(2): 10-17.

[4] 邓红梅, 梁春营, 陈永亨. 水环境中双酚A的污染及其生

态毒理效应[J]. 环境污染与防治, 2009, 31(7): 70-76.
[5] Fuerhacker M. Bisphenol A emission factors from

industrial sources and elimination rates in a sewage

treatment plant [J]. Water Science and Technology,

2003, 47(10): 117-122.

[6] Yamamoto T, Yasuhara A, Shiraishi H, et al.

Bisphenol A in hazardous waste landfill leachates [J].

Chemosphere, 2001, 42(4): 415-418.

[7] Zha J, Wang Z. Acute and early life stage toxicity

of industrial effluent on Japanese medaka (Oryzias

latipes) [J]. Science of the Total Environment, 2006,

357(1/2/3): 112-119.

[8] Le H H, Carlson E M, Chua J P, et al. Bisphenol

A is released from polycarbonate drinking bottles and

mimics the neurotoxic actions of estrogen in developing

cerebellar neurons [J]. Toxicology Letters, 2008,

176(2): 149-156.

[9] Jin X, Jiang G, Huang G, et al. Determination

of 4-tert-octylphenol, 4-nonylphenol and bisphenol A

in surface waters from the Haihe River in Tianjin by

gas chromatography-mass spectrometry with selected

ion monitoring [J]. Chemosphere, 2004, 56(11): 1113-

1119.

[10] Peng X Z, Yu Y J, Tang C M, et al. Occurrence of

steroid estrogens, endocrine-disrupting phenols, and

acid pharmaceutical residues in urban riverine water

of the Pearl River Delta, South China [J]. Science of

the Total Environment, 2008, 397(1/2/3): 158-166.

[11] Gong J, Ran Y, Chen D Y, et al. Occurrence and

environmental risk of endocrine-disrupting chemicals

in surface waters of the Pearl River, South China [J].

Environmental Monitoring and Assessment, 2009,

156(1/2/3/4): 199-210.

[12] Xue X, Wu F, Zhang X, et al. Occurrence of

endocrine disrupting compounds in rivers and lakes

of Wuhan city, China [J]. Fresenius Environmental

Bulletin, 2008, 17(2): 203-210.

[13] Yang F X, Xu Y, Pfister G, et al. Nonylphenol,

bisphenol-A and DDTs in Lake Donghu, China [J].

Fresenius Environmental Bulletin, 2005, 14(3): 173-

180.

[14] Fu M, Li Z, Gao H. Distribution characteristics of

nonylphenol in Jiaozhou Bay of Qingdao and its adjacent

rivers [J]. Chemosphere, 2007, 69(7): 1009-1016.

[15] Gong J, Ran Y, Chen D Y, et al. Occurrence of

endocrine-disrupting chemicals in riverine sediments

from the Pearl River Delta, China [J]. Marine Pollution

Bulletin, 2011, 63(5): 556-563.
[16] Hashimoto S, Horiuchi A, Yoshimoto T, et

al. Horizontal and vertical distribution of estrogenic

activities in sediments and waters from Tokyo Bay,

Japan [J]. Archives of Environmental Contamination

and Toxicology, 2005, 48(2): 209-216.

[17] Khim J S, Lee K T, Kannan K, et al. Trace organic

contaminants in sediment and water from Ulsan Bay

and its vicinity, Korea [J]. Archives of Environmental

Contamination and Toxicology, 2001, 40(2): 141-150.

[18] Stachel B, Ehrhorn U, Heemken O P, et al.

Xenoestrogens in the River Elbe and its tributaries

[J]. Environmental Pollution, 2003, 124(3):

497-507.

[19] Kleˇcka G M, Staples C A, Clark K E, et al.

Exposure analysis of bisphenol A in surface water systems

in North America and Europe [J]. Environmental

Science & Technology, 2009, 43(16): 6145-6150.

[20] Staples C A, Dorn P B, Kleˇcka G M, et al. A

review of the environmental fate, effects, and exposures

of bisphenol A [J]. Chemosphere, 1998, 36(10):

2149-2173.

[21] Kolpin D W, Furlong E T, Meyer M T, et

al. Pharmaceuticals, hormones, and other organic

wastewater contaminants in US streams, 1999—2000:

a national reconnaissance [J]. Environmental Science

& Technology, 2002, 36(6): 1202-1211.

[22] Wu M, Wang L, Xu G, et al. Seasonal and spatial

distribution of 4-tert-octylphenol, 4-nonylphenol and

bisphenol A in the Huangpu River and its tributaries,

Shanghai, China [J]. Environmental Monitoring and

Assessment, 2013, 185: 3149-3161.

[23] Ike M, Jin C S, Fujita M. Biodegradation of

bisphenol A in the aquatic environmental [J]. Water

Science and Technology, 2000, 42(7/8): 31-38.

[24] Klecka G M, Gonsior S J, West R J, et al.

Biodegradation of bisphenol A in aquatic environments:

river die-away [J]. Environmental Toxicology

and Chemistry, 2001, 20(12): 2725-2735.

[25] Voordeckers J W, Fennell D E, Jones K, et al.

Anaerobic biotransfor-mation of tetrabromobisphenol

A, tetrachlorobisphenol A, and bisphenol A in

estuarine sediments [J]. Environmental Science &

Technology, 2002, 36(4): 696-701.

[26] Belfroid A, Van Velzen M, Van Der H B, et

al. Occurrence of bisphenol A in surface water and

uptake in fish: evaluation of field measurements [J].

Chemosphere, 2002, 49(1): 97-103.
[27] Lindholst C, Pedersen K L, Pedersen S N.

Estrogenic response of bisphenol A in rainbow

trout (Oncorhynchus mykiss) [J]. Aquatic Toxicology,

2000, 48(2/3): 87-94.

[28] Honkanen J O, Holopainen I J, Kukkonen J

V. Bisphenol A induces yolk-sac oedema and other

adverse effects in landlocked salmon (Salmo salar m.

sebago) yolk-sac fry [J]. Chemosphere, 2004, 55(2):

187-196.

[29] Ishihara K, Nakajima N. Improvement of marine

environmental pollution using eco-system: decomposition

and recovery of endocrine disrupting chemicals

by marine phyto- and zooplanktons [J]. Journal of

Molecular Catalysis B: Enzymatic, 2003, 23(2): 419-

424.

[30] Tabata A, Kashiwad A S, Ohnishi Y, et al. Estrogenic

influences of estradiol-17 beta, p-nonylphenol

and bisphenol-A on Japanese Medaka (Oryzias

latipes) at detected environmental concentrations [J].

Water Science and Technology, 2001, 43(2): 109-116.

[31] Van Den B K, Verheyen R, Witters H. Comparison

of vitellogenin responses in zebrafish and

rainbow trout following exposure to environmental

estrogens [J]. Ecotoxicology and Environmental

Safety, 2003, 56(2): 271-281.

[32] Brian J V, Harris C A, Scholze M, et al. Accurate

prediction of the response of freshwater fish to

a mixture of estrogenic chemicals [J]. Environmental

Health Perspectives, 2005, 113(6): 721-728.

[33] Arukwe A, Celius T, Walther B T, et al. Effects

of xenoestrogen treatment on zona radiata protein

and vitellogenin expression in Atlantic salmon (Salmo

salar) [J]. Aquatic Toxicology, 2000, 49(3): 159-170.

[34] Lee C, Na J G, Lee K C, et al. Choriogenin

mRNA induction in male medaka, Oryzias latipes as

a biomarker of endocrine disruption [J]. Aquatic Toxicology,

2002, 61(3/4): 233-241.

[35] Nishizawa H, Morta M, Sugimoto M, et al.

Effects of in utero exposure to bisphenol A on mRNA

expression of arlhydrocarbon and retinaoid receptors

in murine embryos [J]. Journal of Reproduction and

Development, 2005, 51(3): 315-324.

[36] 林浩然. 鱼类生理学[M]. 广州: 中山大学出版社, 2011:

240-306.

[37] Sohoni P, Tyler C R, Hurd K, et al. Reproductive

effects of long-term exposure to bisphenol a in

the fathead minnow (Pimephales promelas) [J]. Environmental

Science & Technology, 2001, 35(14): 2917-

2925.
[38] Lee Y M, Seo J S, Kim I C, et al. Endocrine

disrupting chemicals (bisphenol A, 4-nonylphenol, 4-

tert-octylphenol) modulate expression of two distinct

cytochrome P450 aromatase genes differently in

gender types of the hermaphroditic fish Rivulus

marmoratus [J]. Biochemical Biophysical Research

Communications, 2006, 345(2): 894-903.

[39] KishidA M, Mclellan M, Miranda J A, et al.

Estrogen and xenoestrogens upregulate the brain

aromatase isoform (P450aromB) and perturb markers

of early development in zebrafish (Danio rerio)

[J]. Comparative Biochemistry and Physiology

Part B: Biochemistry & Molelular Biology, 2001,

129(2/3): 261-268.

[40] Kang I J, Yokota H, Oshima Y, et al. Effects of

bisphenol A on the reproduction of Japanese medaka

(Oryzias latipes) [J]. Environmental Toxicology and

Chemistry, 2002, 21(11): 2394-2400.

[41] Haubruge E, Petit F, Gage M J. Reduced sperm

counts in guppies (Poecilia reticulata) following

exposure to low levels of tributyltin and bisphenol

A [J]. Proceedings of the Royal Society B: Biological

Sciences, 2000, 267(1459): 2333-2337.

[42] Lahnsteiner F, Berger B, Kletzl M, et al. Effect

of bisphenol A on maturation and quality of semen

and eggs in the brown trout, Salmo trutta f. fario [J].

Aquatic Toxicology, 2005, 75(3): 213-224.

[43] Hatef A, Alavi S M, Abdulfatah A, et al.

Adverse effects of bisphenol A on reproductive physiology

in male goldfish at environmentally relevant

concentrations [J]. Ecotoxicology and Environmental

Safety, 2012, 76(2): 56-62.

[44] Ramakrishnan S, Wayne N L. Impact of bisphenol

A on early embryonic development and reproductive

maturation [J]. Reproductive Toxicology, 2008, 25(2):

177-183.

[45] Chan W K, Chan K M. Disruption of the

hypothalamic-pituitary-thyroid axis in zebrafish

embryo-larvae following waterborne exposure to

BDE-47, TBBPA and BPA [J]. Aquatic Toxicology,

2012, 108: 106-111.

[46] Mandich A, Bottero S, Benfenati E, et al.

In vivo exposure of carp to graded concentrations

of bisphenol A [J]. General and Comparative Endocrinology,

2007, 153(1/2/3): 15-24.

[47] Yokota H, Tsuruda Y, Maeda M, et al. Effect

of bisphenol A on the early life stage in Japanese

medaka (Oryzias latipes) [J]. Environmental Toxicology

and Chemistry, 2000, 19(7): 1925-1930.
[48] Milla S, Depiereux S, Kestemont P. The effects

of estrogenic and androgenic endocrine disruptors on

the immune system of fish: a review [J]. Ecotoxicology,

2011, 20(2): 305-319.

[49] Thilagam H, Gopalakrishnan S, Bo J, et al.

Effect of 17 beta-estradiol on the immunocompetence

of Japanese sea bass (Lateolabrax japonicus) [J].

Environmental Toxicology and Chemistry, 2009,

28(8): 1722-1731.

[50] Harikrishnan T, Singaram G, Bo J, et al. The

effect of 17b-estradiol on the immunocompetence

of Japanese sea bass (Lateolabrax japonicus) [J].

Environmental Toxicology and Chemistry, 2009,

28(8): 1722-1731.

[51] Yin D Q, Hu S Q, Gu Y, et al. Immunotoxicity of

bisphenol A to Carassius auratus lymphocytes and

macrophages following in vitro exposure [J]. Journal

of Environmental Sciences, 2007, 19(2): 232-237.

[52] Watanuki H, Yamaguchi T, Sakai M. Suppression

in function of phagocytic cells in common carp Cyprinus

carpio L. injected with estradiol, progesterone

or 11-ketotestosterone [J]. Comparative Biochemistry

and Physiology Part C: Toxicology and Pharmacology,

2002, 132(4): 407-413.

[53] Yamaguchi T, Watanuki H, Sakai M. Effects of

estradiol, progesterone and testosterone on the function

of carp, Cyprinus carpio, phagocytes in vitro [J].

Comparative Biochemistry and Physiology Part C:

Toxicology and Pharmacology, 2001, 129(1): 49-55.

[54] Jin Y, Chen R, Liu W, et al. Effect of endocrine

disrupting chemicals on the transcription of genes

related to the innate immune system in the early

developmental stage of zebrafish (Danio rerio) [J].

Fish & Shellfish Immunology, 2010, 28(5/6): 854-861.

[55] Moens L N, Van D V K, Van Remortel P, et

al. Expression profiling of endocrine-disrupting compounds

using a customized Cyprinus carpio cDNA

microarray [J]. Toxicological Sciences, 2006, 93(2):

298-310.

[56] Wu M, Xu H, Shen Y, et al. Oxidative stress in

zebrafish embryos induced by short-term exposure

to bisphenol A, nonylphenol, and their mixture [J].

Environmntal Toxicology and Chemistry, 2011,

30(10): 2335-2341.

[57] Xu H, Yang M, Qiu W, et al. The impact of

endocrine-distruting chemicals on oxidative stress

and innate immune response in zebrafish embyros

[J]. Envrionmental Toxicology and Chemistry, 2013,

32(8): 1793-1799.
[58] Rubtsov A V, Rubtsova K, Kappler J W, et

al. Genetic and hormonal factors in female-biased

autoimmunity [J]. Autoimmunity Reviews, 2010,

9(7): 494-498.

[59] Miao S, Gao Z, Kou Z, et al. Influence of bisphenol

a on developing rat estrogen receptors and some

cytokines in rats: a two-generational study [J]. Journal

of Toxicology and Environmental Health A, 2008,

71(15): 1000-1008.

[60] Bonefeld-Jorgensen E C, Long M, Hofmeister

M V, et al. Endocrine-disrupting potential of bisphenol

A, bisphenol A dimethacrylate, 4-n-nonylphenol,

and 4-n-octylphenol in vitro: new data and a brief

review [J]. Environmental Health Perspectives, 2007,

115(S1): 69-76.

[61] Tsigos C, Chrousos G P. Hypothalamic-pituitaryadrenal

axis, neuroendocrine factors and stress [J].

Journal of Psychosomatic Research, 2002, 53(4): 865-

871.

[62] Sathyanarayana S, Braun J M, Yolton K, et

al. Case report: high prenatal bisphenol a exposure

and infant neonatal neurobehavior [J]. Environmental

Health Perspectives, 2011, 119(8): 1170-1175.

[63] Suzuki T, Mizuo K, Nakazawa H, et al. Prenatal

and neonatal exposure to bisphenol-A enhances

the central dopamine D1 receptor-mediated action in

mice: enhancement of the methamphetamine-induced

abuse state [J]. Neuroscience, 2003, 117(3): 639-644.
[64] Mizuo K, Narita M, Yoshida T, et al. Functional

changes in dopamine D3 receptors by prenatal

and neonatal exposure to an endocrine disruptor

bisphenol-A in mice [J]. Addiction Biology,

2004, 9(1): 19-25.

[65] Iwakura T, Iwafuchi M, Muraoka D, et al. In

vitro effects of bisphenol A on developing hypothalamic

neurons [J]. Toxicology, 2010, 272(1/2/3): 52-58.

[66] Lee Y M, Seong M J, Lee J W, et al. Estrogen

receptor independent neurotoxic mechanism of

bisphenol A, an environmental estrogen [J]. Journal

of Veterinary Science, 2007, 8(1): 27-38.

[67] Veerann A, Shetty K T, Takahashi M, et al.

Cdk5 and MAPK are associated with complexes of

cytoskeletal proteins in rat brain [J]. Molecular Brain

Research, 2000, 76(2): 229-236.

[68] Negishi T, Ishii Y, Kyuwa S, et al. Inhibition of

staurosporine-induced neuronal cell death by bisphenol

A and nonylphenol in primary cultured rat hippocampal

and cortical neurons [J]. Neuroscience Letters,

2003, 353(2): 99-102.

[69] Vom S F S, Hughes C. An extensive new literature

concerning low-dose effects of bisphenol A shows the

need for a new risk assessment [J]. Environmental

Health Perspectives, 2005, 113(8): 926-933.

[70] Wolstenholme J T, Rissman E F, Connelly

J J. The role of bisphenol A in shaping the brain,

epigenome and behavior [J].Hormones and Behavior,

2011, 59(3): 296-305.