前列地尔对急性心肌梗死后左室重构的影响

doi:10.3969/j.issn.1007-2861.2016.03.015

上海大学学报(自然科学版) ›› 2016, Vol. 22 ›› Issue (3): 371-375.doi: 10.3969/j.issn.1007-2861.2016.03.015

前列地尔对急性心肌梗死后左室重构的影响

詹丽1,2, 许嘉鸿1

1. 同济大学医学院附属同济医院心内科, 上海200065;
2. 宁波市镇海区人民医院心电图室, 浙江宁波315202

收稿日期:2016-04-19 出版日期:2016-06-30 发布日期:2016-06-30
通讯作者: 许嘉鸿(1969—), 男, 主任医师, 博士生导师, 博士, 研究方向为微小RNA在运动诱导心肌肥大中的作用. E-mail: xujiahong@tongji.edu.cn
作者简介:许嘉鸿(1969—), 男, 主任医师, 博士生导师, 博士, 研究方向为微小RNA在运动诱导心肌肥大中的作用. E-mail: xujiahong@tongji.edu.cn
基金资助:
国家自然科学基金资助项目(81470515, 81270314)；上海市科委医学引导(重点)基金资助项目(134119a3000)

Influence of alprostadil on preventing left ventricular remodeling after acute myocardial infarction

ZHAN Li1,2, XU Jiahong1

1. Department of Cardiology, Tongji Hospital Affiliated to Medical College of Tongji University, Shanghai 200065, China;
2. Department of ECG, Zhenhai District People’s Hospital, Ningbo 315202, Zhejiang, China

Received:2016-04-19 Online:2016-06-30 Published:2016-06-30

摘要/Abstract

摘要：

探讨前列地尔防治急性心肌梗死后左室重构的临床效果. 同期选取2010 年6 月—2015 年12 月于同济医院住院治疗的73 例急性心肌梗死患者, 将患者随机分为常规治疗组和前列地尔治疗组, 两组患者均采用冠心病常规治疗方法进行治疗, 包括休息、吸氧、调脂、扩冠、双联抗血小板等对症支持治疗. 前列地尔组在上述治疗基础上增加前列地尔注射液治疗, 10 μg 前列地尔注射液加入0.9% 氯化钠注射液10 mL 静脉推注, 1 次/d.连续治疗7 d. 治疗28 d 后, 常规治疗组左室舒张末期内径(left ventricular end-diastolic dimension, LVDd)、左室收缩末期内径(left ventricular end-systolic dimension, LVDs)、室间隔厚度(interventricular septal thickness, IVST)、左室后壁舒张末期厚度(left ventricular posterior wall end-diastolic, LVPWd)、射血分数(ejection fraction, EF)、E峰/A峰比值较治疗3 d 后无显著改善(P >0.05); 前列地尔组在治疗28 d 后与治疗3 d 后相比, LVDd, LVDs, E 峰/A 峰比值有明显减小, EF 值明显升高(均达到P <0.05), IVST 与LVPWd 变化不明显. 前列地尔在短期内对急性心肌梗死后心功能有改善作用, 对左室重构影响不大.

关键词: 急性心肌梗死 , 左室重构, 前列地尔

Abstract:

To investigate the clinic effect of alprostadil on preventing left ventricular remodeling after acute myocardial infarction (AMI). A total of 73 cases of AMI were randomly divided into two groups: basic treatment group and alprostadil treatment group. Both groups were given basic treatments such as rest, oxygen inhalation, dual antiplatelet therapy. Alprostadil was intravenously injected in the alprostadil treatment group, 10 μg once a day for 7 days. Left ventricular end-diastolic dimension (LVDd), left ventricular end-systolic dimension (LVDs), interventricular septal thickness (IVST), left ventricle posterior wall end-diastolic (LVPWd), ejection fraction (EF) and E/A ratio were measured by echocardiography on the 3rd and the 28th days after treatment. Compared to the 3rd day after treatment, LVDd, LVDs, IVST, LVPWd, EF, E/A ratio in the basic treatment group had no significant changes on the 28th day after treatment. LVDd, LVDs, E/A ratio in the alprostadil treatment group on the 28th day after treatment were significantly reduced in comparison with the 3rd day after treatment (P <0.05) while IVST and LVPWd showed no significant changes. Alprostadil improves cardiac function after acute myocardial infarction in short term, but has no influence on preventing left ventricular remodeling.

Key words: acute myocardial infarction , left ventricular remodeling, alprostadil

詹丽1,2, 许嘉鸿1. 前列地尔对急性心肌梗死后左室重构的影响[J]. 上海大学学报(自然科学版), 2016, 22(3): 371-375.

ZHAN Li1,2, XU Jiahong1. Influence of alprostadil on preventing left ventricular remodeling after acute myocardial infarction[J]. Journal of Shanghai University（Natural Science Edition）, 2016, 22(3): 371-375.

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前列地尔对急性心肌梗死后左室重构的影响

Influence of alprostadil on preventing left ventricular remodeling after acute myocardial infarction

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