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Journal of Shanghai University >

2018 , Vol. 24 >Issue 5: 800 - 806

DOI: https://doi.org/10.12066/j.issn.1007-2861.1825

Research Articles

Inhibition of endogenous H$_\textbf{2}$S concentrations in human hepatocyte L02 cells by 1-chloro-2-hydroxy-3-butene

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  • Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

Received date: 2016-10-07

  Online published: 2018-10-26

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Abstract

1-chloro-2-hydroxy-3-butene (CHB) is a metabolite of 1,3-butadiene, an environmental pollutant. CHB is cytotoxic, genotoxic, and mutagenic. H$_2$S is the third gasotransmitter following NO and CO, and is involved in a variety of physiological activities. Abnormal metabolism of H$_2$S is associated with many diseases. In the present study, the effect of CHB on the concentrations of endogenous H$_2$S in human hepatocyte L02 cells was investigated. It was observed that CHB could cause significant decreases in the concentrations of endogenous H$_2$S in the cells and the effect depended on CHB concentration. Thus, inhibition of endogenous H$_2$S production in cells by CHB may be a mechanism for toxicity of CHB, which can contribute to a better understanding of toxicity of 1,3-butadiene.

Key words： 1-chloro-2-hydroxy-3-butene (CHB); H$_2$S; 1,3-butadiene; toxicity

Cite this article

ZHANG Fang, ZHANG Xinyu . Inhibition of endogenous H$_\textbf{2}$S concentrations in human hepatocyte L02 cells by 1-chloro-2-hydroxy-3-butene[J]. Journal of Shanghai University, 2018 , 24(5) : 800 -806 . DOI: 10.12066/j.issn.1007-2861.1825

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