Dynamics of HIV spreading in network of immune system in vivo
Received date: 2016-03-10
Online published: 2017-12-30
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus (HIV), body virus sanctuary seems to exist. This study
explores whether the virus sanctuary does exist. Our findings show that, due to bloodbrain barrier, viral load in brain remains at a high steady state even antiviral therapy is followed. This suggests that brain is the sanctuary of HIV virus. In addition, we have also found that level of virus in the peripheral blood may not correctly reflect what is occurring inside the body.
HUANG Ying, LOU Jie . Dynamics of HIV spreading in network of immune system in vivo[J]. Journal of Shanghai University, 2017 , 23(6) : 920 . DOI: 10.12066/j.issn.1007-2861.1808
[1] Shen L, Siliciano R F. Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection [J]. Journal of Allergy and Clinical Immunol,
2008, 122(1): 22-28.
[2] Perelson A S, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy [J]. Nature, 1997, 387(6629): 188-191.
[3] Haase A T, Henry K, Zupancic M, et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue [J]. Science, 1996, 274(5289): 985-989.
[4] Hamed K A, Winters M A, Holodniy M. et al. Detection of human immunodeficiency virus type 1 in semen: effects of disease stage and nucleoside therapy [J]. Journal of Infectious Diseases, 1993, 167(4): 798-802.
[5] Vernazza P L, Eron J J, CohenMS, et al. Detection and biologic characterization of infectious HIV-1 in semen of seropositive men [J]. AIDS, 1994, 8(9): 1325-1329.
[6] Levy J A. HIV and the pathogenesis of AIDS [M]. 3rd ed. Washington: ASM Press, 2007.
[7] Barker C F, Billingham R E. Immunologically privileged sites [J]. Advances in Immunology, 1978, 25: 1-54.
[8] Callaway D S, Perelson A S. HIV-1 infection and low steady state viral loads [J]. Bulletin of Mathematical Biology, 2002, 64(1): 29-64.
[9] van den Driessche P, Watmough J. Reproduction numbers and sub-threshold endemic equilibrium for compartmental models of disease transmission [J]. Mathematical Biosciences, 2002, 180(1/2): 29-48.
[10] Blower S M, Gershengorn H B, Grant R M. A tale of two futures: HIV and antiretroviral therapy in San Francisco [J]. Science, 2000, 287(5453): 650-654.
[11] Lou J, Lou Y J, Wu J H. Threshold virus dynamics with impulsive antiretroviral drug effects[J]. Journal of Mathematical Biology, 2012, 65(4): 623-652.
[12] Perelson A S, Essvnger P, Cao Y, et al. Decay characteristics of HIV-infected compartments during combination therapy [J]. Nature, 1997, 387(6629): 188-191.
/
| 〈 |
|
〉 |
