Journal of Shanghai University(Natural Science Edition) ›› 2017, Vol. 23 ›› Issue (6): 920-.doi: 10.12066/j.issn.1007-2861.1808

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Dynamics of HIV spreading in network of immune system in vivo

HUANG Ying, LOU Jie   

  1. College of Sciences, Shanghai University, Shanghai 200444, China 
  • Received:2016-03-10 Online:2017-12-30 Published:2017-12-30

Abstract:

Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus (HIV), body virus sanctuary seems to exist. This study
explores whether the virus sanctuary does exist. Our findings show that, due to bloodbrain barrier, viral load in brain remains at a high steady state even antiviral therapy is followed. This suggests that brain is the sanctuary of HIV virus. In addition, we have also found that level of virus in the peripheral blood may not correctly reflect what is occurring inside the body.

Key words: antiretroviral therapy (ART), lymphocyte recirculation, reproduction number, human immunodeficiency virus (HIV)