KOU Jiayuan1, JIANG Yueqing1, TIAN Ye1,2, YANG Liming1 . Application of sonosensitizers derived from Chinese herb products in sonodynamic therapy for atherosclerosis treatment[J]. Journal of Shanghai University, 2016 , 22(3) : 318 -325 . DOI: 10.3969/j.issn.1007-2861.2016.03.012

[1] Lotta L A. Genome-wide association studies in atherothrombosis [J]. European Journal of Internal Medicine, 2010, 21(2): 74-78.
[2] Mozaffarian D, Benjamin E J, Go A S, et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association [J]. Circulation, 2014, 131(4): e29-e322.
[3] Ferguson J J, Kereiakes D J, Adgey A A, et al. Safe use of platelet GP Ⅱb/Ⅲa inhibitors [J]. American Heart Journal, 1998, 135(4): D40-D51.
[4] Neuvonen P J, Mikko N, Backman J T. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance [J]. Clinical Pharmacology and Therapeutics, 2007, 80(6): 565-581.
[5] Rockson S G, Lorenz D P, Cheong W F, et al. Photoangioplasty an emerging clinical cardiovascular role for photodynamic therapy [J]. Circulation, 2000, 102(5): 591-596.

[6] Chen H, Zhou X, Yu G, et al. Recent progress in development of new sonosensitizers for sonodynamic cancer therapy [J]. Drug Discovery Today, 2014, 19(4): 502-509.
[7] Sgolastra F, Petrucci A, Gatto R, et al. Photodynamic therapy in the treatment of chronic periodontitis: a systematic review and Meta-analysis [J]. Lasers in Medical Science, 2013, 28(2): 669-682.
[8] Maria K, Konstantinos T, Archontoula M, et al. Vulnerable plaque and inflammation: potential clinical strategies [J]. Curr Pharm Des, 2011, 17(37): 4190-4209.
[9] Martijn T, Paul B, Schellens J H M, et al. Photodynamic therapy in oncology [J]. Oncologist, 2006, 11(9): 1034-1044.
[10] Yumita N, Nishigaki R, Umemura K, et al. Hematoporphyrin as a sensitizer of cell-damaging effect of ultrasound [J]. Jpn J Cancer Res, 1989, 80(3): 219-222.
[11] Bailey M R, Khokhlova V A, Sapozhnikov O A, et al. Physical mechanisms of the therapeutic effect of ultrasound (a review) [J]. Acoustical Physics, 2003, 49(4): 369-388.
[12] Kuroki M, Hachimine K H, Shibaguchi H, et al. Sonodynamic therapy of cancer using novel sonosensitizers [J]. Anticancer Research, 2007, 27(6A): 3673-3678.
[13] Shi J, Chen Z, Wang B, et al. Reactive oxygen species-manipulated drug release from a smart envelope-type mesoporous titanium nanovehicle for tumor sonodynamic-chemotherapy [J]. ACS Applied Materials and Interfaces, 2015, 7(51): 28554-28565.
[14] Rosenthal I, Sostaric J Z, Riesz P. Sonodynamic therapy—a review of the synergistic effects of drugs and ultrasound [J]. Ultrasonics Sonochemistry, 2004, 11(6): 349-363.
[15] Hirotomo S, Hirofumi T, Motomu K, et al. Sonodynamic cancer therapy: a non-invasive and repeatable approach using low-intensity ultrasound with a sonosensitizer [J]. Anticancer
Research, 2011, 31(7): 2425-2429.
[16] Baker K G, Robertson V J, Duck F A. A review of therapeutic ultrasound: biophysical effects [J]. Physical Therapy, 2001, 81(7): 1351-1358.
[17] Suslick K S. Ultrasound: its chemical, physical and biological effects [M]. Weinheim: Vch Publishers, 1988.
[18] Apfel R E. Acoustic cavitation: a possible consequence of biomedical uses of ultrasound [J]. British Journal of Cancer Supplement, 1982, 5(1): 140-146.
[19] David C, Conor M E, Colin F, et al. Treating cancer with sonodynamic therapy: a review [J]. International Journal of Hyperthermia the Official Journal of European Society for Hyperthermic Oncology North American Hyperthermia Group, 2015, 31(2): 107-117.
[20] Li Y, Pan W, Ping Z, et al. Apoptosis induced by sonodynamic treatment by protoporphyrin Ⅸ on MDA-MB-231 cells [J]. Ultrasonics, 2012, 52(4): 490-496.
[21] Xin S, Xu H, Jing S, et al. Real-time detection of intracellular reactive oxygen species and mitochondrial membrane potential in THP-1 macrophages during ultrasonic irradiation for optimal sonodynamic therapy [J]. Ultrasonics Sonochemistry, 2015, 22: 7-14.
[22] Zheng L, Sun X, Zhu X, et al. Apoptosis of THP-1 derived macrophages induced by sonodynamic therapy using a new sonosensitizer hydroxyl acetylated curcumin [J]. PLoS One, 2014, 9(3): e93133.
[23] Cheng J, Sun X, Guo S, et al. Effects of 5-aminolevulinic acid-mediated sonodynamic therapy on macrophages [J]. International Journal of Nanomedicine, 2013, 8(1): 669-676.

[24] Tao L, Hui J, Sun Q R, et al. Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity [J]. Brain Research, 2010, 1347(1): 149-160.
[25] Qin H, Mazhar N, Yuen F W, et al. In vitro anti-fibrotic activities of herbal compounds and herbs [J]. Nephrology Dialysis Transplantation, 2009, 24(10): 3033-3041.
[26] Cai J, Razzak A, Hering J, et al. Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro [J]. Journal of Parenteral and Enteral
Nutrition, 2008, 32(2): 357-360.
[27] Esther B, Geert C, Nico H, et al. Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy [J]. FASEB Journal, 2006, 20(6): 756-758.
[28] Gao Q, Wang F, Guo S, et al. Sonodynamic effect of an anti-inflammatory agent—emodin on macrophages [J]. Ultrasound in Medicine and Biology, 2011, 37(9): 1478-1485.
[29] Buhrmann C, Mobasheri A, Busch F, et al. Curcumin modulates NF-B-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase-Akt pathway [J]. Journal of Biological Chemistry, 2011, 286(32): 28556-28566.
[30] Samuhasaneeto S, Thong-Ngam D, Kulaputana O, et al. Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats [J]. Journal of Biomedicine and Biotechnology, 2009, 2009(1): 981963.
[31] Issei D, Yunkyung H, Noriyuki Y, et al. Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents [J]. Bioscience Biotechnology and Biochemistry, 2010, 74(1): 185-187.
[32] Wang F, Gao Q, Guo S, et al. The sonodynamic effect of curcumin on THP-1 cell-derived macrophages [J]. Biomed Research International, 2013, 2013(1): 121-128.
[33] Sarris J, Panossian A, Schweitzer I, et al. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence [J]. European Neuropsychopharmacology, 2011, 21(12): 841-860.
[34] Ehrenshaft M, Roberts J E, Mason R P. Hypericin-mediated photooxidative damage of-crystallin in human lens epithelial cells [J]. Free Radical Biology and Medicine, 2013, 60:
347-354.
[35] Boˇzin B, Kladar N, Gruji´c N, et al. Impact of origin and biological source on chemical composition, anticholinesterase and antioxidant properties of some St. John’sWort Species (Hypericum spp., Hypericaceae) from the central balkans [J]. Molecules, 2013, 18(18): 11733-11750.
[36] Li X, Gao L, Zheng L, et al. The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages [J]. International Journal of
Nanomedicine, 2015, 10: 821-838.
[37] Kerb R, Brockm¨oller J, Staffeldt B, et al. Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin [J]. Antimicrobial Agents and Chemotherapy, 1996, 40(9): 2087-2093.
[38] Lv Y, Fang M, Zheng J, et al. Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma [J]. Cellular Physiology and Biochemistry, 2012, 30(2): 321-333.[39] He Y, Xia X, Xu C, et al. 5-aminolaevulinic acid enhances ultrasound-induced mitochondrial damage in K562 cells [J]. Ultrasonics, 2010, 50(8): 777-781.
[40] Barbara K, Kristjan P. ALA and its clinical impact, from bench to bedside [J]. Photochemical and Photobiological Sciences, 2008, 7(3): 283-289.
[41] Song W, Cui H, Zhang R, et al. Apoptosis of SAS cells induced by sonodynamic therapy using 5-aminolevulinic acid sonosensitizer [J]. Anticancer Research, 2011, 31(1): 39-45.
[42] Chen H, Gao W, Yang Y, et al. Inhibition of VDAC1 prevents Ca2+-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages [J]. Apoptosis, 2014, 19(12): 1712-1726.
[43] Rensen S S M, Doevendans P A F M, Eys G J J M V. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity [J]. Netherlands Heart Journal, 2007, 15(3):
100-108.
[44] Chen K H, Guo X, Ma D, et al. Dysregulation of HSG triggers vascular proliferative disorders [J]. Nature Cell Biology, 2004, 6(9): 872-883.
[45] Dan J, Sun X, Li W, et al. 5-aminolevulinic acid-mediated sonodynamic therapy promotes phenotypic switching from dedifferentiated to differentiated phenotype via reactive oxygen species and p38 mitogen-activated protein kinase in vascular smooth muscle cells [J]. Ultrasound in Medicine and Biology, 2015, 41(6): 1681-1689.
[46] Moore K J, Tabas I. Macrophages in the pathogenesis of atherosclerosis [J]. Cell, 2011, 145(3): 341-355.
[47] Ira T, Kevin J W, Jan B. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications [J]. Circulation, 2007, 116(16): 1832-1844.
[48] Wang H, Yang Y, Chen H, et al. The predominant pathway of apoptosis in THP-1 macrophagederived foam cells induced by 5-aminolevulinic acid-mediated sonodynamic therapy is the mitochondria-caspase pathway despite the participation of endoplasmic reticulum stress [J]. Cellular Physiology and Biochemistry, 2014, 33(6): 1789-1801.
[49] Li Z, Sun X, Guo S, et al. Rapid stabilisation of atherosclerotic plaque with 5-aminolevulinic acid-mediated sonodynamic therapy [J]. Thrombosis and Haemostasis, 2015, 114(4): 793-803.
[50] Tian F, Yao J, Yan M, et al. 5-aminolevulinic acid-mediated sonodynamic therapy inhibits RIPK1/RIPK3-dependent necroptosis in THP-1-derived foam cells [J]. Scientific Reports, 2016, 6: 21992.
[51] Chung J, Chen C, Paw B H. Heme metabolism and erythropoiesis [J]. Current Opinion in Hematology, 2012, 19(3): 156-162.
[52] Peng C, Li Y, Liang H, et al. Detection and photodynamic therapy of inflamed atherosclerotic plaques in the carotid artery of rabbits [J]. Journal of Photochemistry and Photobiology B Biology, 2011, 102(1): 26-31.
[53] Moore K J, Sheedy F J, Fisher E A. Macrophages in atherosclerosis: a dynamic balance [J]. Nature Reviews Immunology, 2013, 13(10): 709-721.
[54] Guo S, Sun X, Cheng J, et al. Apoptosis of THP-1 macrophages induced by protoporphyrin Ⅸ-mediated sonodynamic therapy [J]. International Journal of Nanomedicine, 2013, 8(13): 2239-2246.