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Journal of Shanghai University >

2023 , Vol. 29 >Issue 2: 211

DOI: https://doi.org/10.12066/j.issn.1007-2861.2457

Research progress of non-coding RNAs in liver cancer

  • YANG Qianqian ,
  • TIAN Hui ,
  • WANG Guangzhi ,
  • MA Zhongliang
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  • 1. Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China; 2. Zhongshan Hospital, Fudan University, Shanghai 200032, China; 3. A±liated Hospital of Weifang Medical University, Weifang 261053, Shandong, China

Received date: 2022-09-17

  Online published: 2023-04-30

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Abstract

Liver cancer is the leading global lethal malignancy. Hypoxia in the tumor microenvironment is a hallmark of the tumor microenvironment, and hypoxia-inducible factor-1a is the most important transcriptional regulator in response to hypoxia. Non- coding RNA (ncRNA) play a crucial role in regulating the pathogenesis and progression of hepatocellular carcinoma (HCC). This review comprehensively summarizes the pathological roles of ncRNA in hepatocarcinogenesis, epithelial-mesenchymal transition, and angiogen- esis under hypoxic environments, and discusses the potential applications of ncRNA as diagnostic tools and therapeutic targets for human HCC.

Key words： HIF-1a; non-coding RNA; liver cancer; tumor microenvironment

Cite this article

YANG Qianqian , TIAN Hui , WANG Guangzhi , MA Zhongliang . Research progress of non-coding RNAs in liver cancer[J]. Journal of Shanghai University, 2023 , 29(2) : 211 . DOI: 10.12066/j.issn.1007-2861.2457

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