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Journal of Shanghai University >

2022 , Vol. 28 >Issue 5: 821 - 830

DOI: https://doi.org/10.12066/j.issn.1007-2861.2441

Advances in the mechanism of piRNA regulating cardiovascular disease

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  • 1. Institute of Cardiovascular Sciences, School of Life Sciences, Shanghai University, Shanghai 200444, China
    2. Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China

Received date: 2022-08-08

  Online published: 2022-11-12

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Abstract

PIWI-interacting RNA (piRNA), a new type of endogenous non-coding RNA, was identified from germ cells. Approximately 30 nt long, piRNA plays an important role in regulating physical or pathological processes, including maintaining genomic integrity, via interacting with the PIWI protein family. Research advancements confirms that piRNA is widely expressed in several other tissues and cells. Cardiovascular disease (CVD) is a leading cause of mortality worldwide. The present review summarizes the role and underlying mechanism of piRNA in CVD models upon their biogenesis process and tissue distribution. It also examines CVD diagnosis- and treatment-associated patents. These rrsults may help enrich the molecular biological theory of piRNA and provide potential targets and strategies for the treatment of CVD.

Key words： cardiovascular disease(CVD); piRNA; diagnosis; drug development patents

Cite this article

XIE Jinxin, YANG Zijiang, WANG Hongyun, XIAO Junjie . Advances in the mechanism of piRNA regulating cardiovascular disease[J]. Journal of Shanghai University, 2022 , 28(5) : 821 -830 . DOI: 10.12066/j.issn.1007-2861.2441

References

[1] Aravin A, Gaidatzis D, Pfeffer S, et al. A novel class of small RNAs bind to MILI protein in mouse testes[J]. Nature, 2006, 442(7099): 203-207.
[2] Girard A, Sachidanandam R, Hannon G J, et al. A germline-specific class of small RNAs binds mammalian PIWI proteins[J]. Nature, 2006, 442(7099): 199-202.
[3] Brennecke J, Aravin A A, Stark A, et al. Discrete small RNA-generating loci as master regulators of transposon activity in drosophila[J]. Cell, 2007, 128(6): 1089-1103.
[4] Zeng Q, Cai J, Wan H, et al. PIWI-interacting RNAs and PIWI proteins in diabetes and cardiovascular disease: molecular pathogenesis and role as biomarkers[J]. Clin Chim Acta, 2021, 518: 33-37.
[5] La-Greca A, Scarafia M A, Hernandez C M C, et al. PIWI-interacting RNAs are differentially expressed during cardiac differentiation of human pluripotent stem cells[J]. PLoS One, 2020, 15(5): e0232715.
[6] Li M, Yang Y, Wang Z, et al. PIWI-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases[J]. Angiogenesis, 2021, 24(1): 19-34.
[7] Houwing S, Kamminga L M, Berezikov E, et al. A role for PIWI and piRNAs in germ cell maintenance and transposon silencing in zebrafish[J]. Cell, 2007, 129(1): 69-82.
[8] Ipsaro J J, Haase A D, Knott S R, et al. The structural biochemistry of zucchini implicates it as a nuclease in piRNA biogenesis[J]. Nature, 2012, 491(7423): 279-283.
[9] Mohn F, Handler D, Brennecke J. piRNA-guided slicing specifies transcripts for zucchini-dependent, phased piRNA biogenesis[J]. Science, 2015, 348(6236): 812-817.
[10] Han B W, Wang W, Li C, et al. Noncoding RNA. piRNA-guided transposon cleavage initiates zucchini-dependent, phased piRNA production[J]. Science, 2015, 348(6236): 817-821.
[11] Tang W, Tu S, Lee H C, et al. The RNase PARN-1 Trims piRNA 3' ends to promote transcriptome surveillance in C. elegans[J]. Cell, 2016, 164(5): 974-984.
[12] Izumi N, Shoji K, Sakaguchi Y, et al. Identification and functional analysis of the pre-piRNA 3' trimmer in silkworms[J]. Cell, 2016, 164(5): 962-973.
[13] Horwich M D, Li C, Matranga C, et al. The drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC[J]. Curr Biol, 2007, 17(14): 1265-1272.
[14] Kirino Y, Mourelatos Z. Mouse PIWI-interacting RNAs are 2'-O-methylated at their 3' termini[J]. Nat Struct Mol Biol, 2007, 14(4): 347-348.
[15] Saito K, Sakaguchi Y, Suzuki T, et al. Pimet, the drosophila homolog of HEN1, mediates 2'-O-methylation of PIWI-interacting RNAs at their 3' ends[J]. Genes Dev, 2007, 21(13): 1603-1608.
[16] Wang W, Yoshikawa M, Han B W, et al. The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs[J]. Mol Cell, 2014, 56(5): 708-716.
[17] Gainetdinov I, Colpan C, Arif A, et al. A single mechanism of biogenesis, initiated and directed by PIWI proteins, explains pirna production in most animals[J]. Mol Cell, 2018, 71(5): 775-790.
[18] Wang W, Han B W, Tipping C, et al. Slicing and binding by Ago3 or Aub trigger PIWI-bound piRNA production by distinct mechanisms[J]. Mol Cell, 2015, 59(5): 819-830.
[19] Kuramochi-Miyagawa S, Kimura T, Yomogida K, et al. Two mouse PIWI-related genes: MIWI and MILI[J]. Mech Dev, 2001, 108(1/2): 121-133.
[20] Qiao D, Zeeman A M, Deng W, et al. Molecular characterization of HIWI, a human member of the PIWI gene family whose overexpression is correlated to seminomas[J]. Oncogene, 2002, 21(25): 3988-3999.
[21] Ozata D M, Gainetdinov I, Zoch A, et al. PIWI-interacting RNAs: small RNAs with big functions[J]. Nat Rev Genet, 2019, 20(2): 89-108.
[22] Nagamori I, Kobayashi H, Nishimura T, et al. Relationship between PIWIL4-mediated H3K4me2 demethylation and piRNA-dependent DNA methylation[J]. Cell Rep, 2018, 25(2): 350-356.
[23] Wu D, Fu H, Zhou H, et al. Effects of novel ncRNA molecules, p15-piRNAs, on the methylation of DNA and histone H3 of the CDKN2B promoter region in U937 cells[J]. J Cell Biochem, 2015, 116(12): 2744-2754.
[24] Kutter C, Svoboda P. miRNA, siRNA, piRNA: knowns of the unknown[J]. RNA Biol, 2008, 5(4): 181-188.
[25] Kuramochi-Miyagawa S, Watanabe T, Gotoh K, et al. DNA methylation of retrotransposon genes is regulated by PIWI family members MILI and MIWI2 in murine fetal testes[J]. Genes & Development, 2008, 22(7): 908-917.
[26] Su J F, Zhao F, Gao Z W, et al. piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B[J]. Pathol Res Pract, 2020, 216(4): 152848.
[27] Zhang C, Sha H, Peng Y, et al. PiRNA-DQ541777 contributes to neuropathic pain via targeting Cdk5rap1[J]. J Neurosci, 2019, 39(45): 9028-9039.
[28] Cichocki F, Lenvik T, Sharma N, et al. Cutting edge: KIR antisense transcripts are processed into a 28-base PIWI-like RNA in human NK cells[J]. J Immunol, 2010, 185(4): 2009-2012.
[29] Han H, Fan G, Song S, et al. piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL[J]. Blood, 2021, 137(12): 1603-1614.
[30] Zhong N, Nong X, Diao J, et al. piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure[J]. Aging, 2022, 14(6): 2678-2694.
[31] Yang J, Xue F T, Li Y Y, et al. Exosomal piRNA sequencing reveals differences between heart failure and healthy patients[J]. Eur Rev Med Pharmacol Sci, 2018, 22(22): 7952-7961.
[32] Wang K, Zhou L Y, Liu F, et al. PIWI-interacting RNA HAAPIR regulates cardiomyocyte death after myocardial infarction by promoting NAT10-mediated ac(4)C acetylation of TFEC mRNA[J]. Adv Sci : Weinh, 2022, 9(8): e2106058.
[33] Rajan K S, Velmurugan G, Gopal P, et al. Abundant and altered expression of PIWI-interacting RNAs during cardiac hypertrophy[J]. Heart, Lung & Circulation, 2016, 25(10): 1013-1020.
[34] Lipps C, Northe P, Figueiredo R, et al. Non-invasive approach for evaluation of pulmonary hypertension using extracellular vesicle-associated small non-coding RNA[J]. Biomolecules, 2019, 9(11): 666.
[35] Ma C, Zhang L, Wang X, et al. piRNA-63076 contributes to pulmonary arterial smooth muscle cell proliferation through acyl-CoA dehydrogenase[J]. J Cell Mol Med, 2020, 24(9): 5260-5073.
[36] Gao X Q, Zhang Y H, Liu F, et al. The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of PARP10 mRNA[J]. Nature Cell Biology, 2020, 22(11): 1319-1331.
[37] Wang A, Liu J, Zhuang X, et al. Identification and comparison of piRNA expression profiles of exosomes derived from human stem cells from the apical papilla and bone marrow mesenchymal stem cells[J]. Stem Cells and Development, 2020, 29(8): 511-520.
[38] Wang H, Wang T, Rui W, et al. Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM2.5)-induced cardiac dysfunction via ACE2 signalling[J]. J Extracell Vesicles, 2022, 11(5): e12222.
[39] Wang H, Maimaitiaili R, Yao J, et al. Percutaneous intracoronary delivery of plasma extracellular vesicles protects the myocardium against ischemia-reperfusion injury in canis[J]. Hypertension, 2021, 78(5): 1541-1554.
[40] Tham Y K, Bernardo B C, Ooi J Y, et al. Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets[J]. Arch Toxicol, 2015, 89(9): 1401-1438.
[41] Liao H H, Jia X H, Liu H J, et al. The role of PPARs in pathological cardiac hypertrophy and heart failure[J]. Curr Pharm Des, 2017, 23(11): 1677-1686.
[42] Rajan K S, Velmurugan G, Pandi G, et al. miRNA and piRNA mediated AKT pathway in heart: antisense expands to survive[J]. Int J Biochem Cell Biol, 2014, 55: 153-156.
[43] Pall G S, Codony-Servat C, Byrne J, et al. Carbodiimide-mediated cross-linking of RNA to nylon membranes improves the detection of siRNA, miRNA and piRNA by Northern Blot[J]. Nucleic Acids Res, 2007, 35(8): e60.
[44] Ro S, Park C, Jin J, et al. A PCR-based method for detection and quantification of small RNAs[J]. Biochem Biophys Res Commun, 2006, 351(3): 756-763.
[45] Cui L, Lou Y, Zhang X, et al. Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers[J]. Clin Biochem, 2011, 44(13): 1050-1057.
[46] Galié N, Humbert M, Vachiery J L, et al. 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension[J]. Respiratory Journal, 2015, 46: 903-975.
[47] Humbert M, Farber H W, Ghofrani H A, et al. Risk assessment in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension[J]. The European Respiratory Journal, 2019, 53(6): 1802004.
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