piRNA 调节心血管疾病的分子机制进展

doi:10.12066/j.issn.1007-2861.2441

Abstract

Abstract:

PIWI-interacting RNA (piRNA), a new type of endogenous non-coding RNA, was identified from germ cells. Approximately 30 nt long, piRNA plays an important role in regulating physical or pathological processes, including maintaining genomic integrity, via interacting with the PIWI protein family. Research advancements confirms that piRNA is widely expressed in several other tissues and cells. Cardiovascular disease (CVD) is a leading cause of mortality worldwide. The present review summarizes the role and underlying mechanism of piRNA in CVD models upon their biogenesis process and tissue distribution. It also examines CVD diagnosis- and treatment-associated patents. These rrsults may help enrich the molecular biological theory of piRNA and provide potential targets and strategies for the treatment of CVD.

Key words: cardiovascular disease(CVD), piRNA, diagnosis, drug development patents

CLC Number:

XIE Jinxin, YANG Zijiang, WANG Hongyun, XIAO Junjie. Advances in the mechanism of piRNA regulating cardiovascular disease[J]. Journal of Shanghai University（Natural Science Edition）, 2022, 28(5): 821-830.

Figures/Tables 3

References 47

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Advances in the mechanism of piRNA regulating cardiovascular disease

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