中文

Journal of Shanghai University >

2021 , Vol. 27 >Issue 4: 696 - 705

DOI: https://doi.org/10.12066/j.issn.1007-2861.2170

Research Articles

Effects of different ZnO nanoparticles on ion absorption in human gastric epithelium cells

Expand
  • 1. School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China
    2. Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
    3. Tumor Precision Targeting Research Center, Shanghai University, Shanghai 200444, China

Received date: 2019-03-06

  Online published: 2019-04-16

Fold

Abstract

This paper systematically studied the effects of different types and low concentrations of ZnO nanoparticles (NPs) on the uptake of Fe$^{3+}$, Ca$^{2+}$ and Mg$^{2+}$ in human gastric epithelium cells-1 (GES-1). The results showed that ZnO NPs had the most significant impact on the absorption of Fe$^{3+}$. The changes in the three ion concentrations in GES-1 were related to the size and concentration of ZnO NPs. Among them, the effect of 50 nm ZnO NPs on the absorption of ions was the most significant, reaching the highest concentration at 15 mg/L. However, the hydrophilic and lipophilic properties of ZnO NPs had no obvious effect on the absorption of ions. Finally, the mechanism of ion adsorption was discussed by detecting the cell viability and reactive oxygen species (ROS) levels of different types of ZnO NPs.

Key words： ZnO nanoparticles (NPs); size; concentration; ion absorption

Cite this article

WANG Mimi, WU Minghong, WANG Yanli . Effects of different ZnO nanoparticles on ion absorption in human gastric epithelium cells[J]. Journal of Shanghai University, 2021 , 27(4) : 696 -705 . DOI: 10.12066/j.issn.1007-2861.2170

References

[1] Mirzaei H, Darroudi M. Zinc oxide nanoparticles: biological synjournal and biomedical applications[J]. Ceramics International, 2017, 43(1):907-914.
[2] Smijs T G, Pavel S. Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness[J]. Nanotechnology Science and Applications, 2011(4):95-112.
[3] Perez E, Paula J, Ferreira S, et al. ZnO nanoparticles: synjournal, antimicrobial activity and food packaging applications[J]. Food and Bioprocess Technology, 2012, 5(5):1447-1464.
[4] Bolognesi C, Castle L, Cravedi J P, et al. Safety assessment of the substance zinc oxide, nanoparticles, for use in food contact materials[J]. EFSA Journal, 2016, 14(3):20164408.
[5] Wang Y L, Yuan L L, Yao C J, et al. Caseinophosphopeptides cytoprotect human gastric epithelium cells against the injury induced by zinc oxide nanoparticles[J]. RSC Advance, 2014, 4(79):42168-42174.
[6] Liang T S, Guan R F, Tao M, et al. In vitro toxicity of zinc oxide nanoparticles from food additives in human gastric epithelium (GES-1) cells[J]. Science of Advanced Materials, 2017, 9(8):1393-1400.
[7] Wang Y L, Yuan L L, Yao C J, et al. A combined toxicity study of zinc oxide nanoparticles and vitamin C in food additives[J]. Nanoscale, 2014, 6(24):15333-15342.
[8] Go M R, Yu J, Bae S H, et al. Effects of interactions between ZnO nanoparticles and saccharides on biological responses[J]. International Journal of Molecular Sciences, 2018, 19(2):020486.
[9] Mahler G J, Esch M B, Tako E, et al. Oral exposure to polystyrene nanoparticles affects iron absorption[J]. Nature Nanotechnology, 2012, 7(4):264-271.
[10] Ryazanova L V, Rondon L J, Zierler S, et al. TRPM7 is essential for Mg$^{2+}$ homeostasis in mammals[J]. Nature Communications, 2010, 1:109.
[11] Guo Z Y, Martucci N J, Moreno-Olivas F, et al. Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine[J]. NanoImpact, 2017(5):70-82.
[12] Ognik K, Stepniowska A, Cholewinska E, et al. The effect of administration of copper nanoparticles to chickens in drinking water on estimated intestinal absorption of iron, zinc, and calcium[J]. Poultry Science, 2016, 95(9):2045-2051.
[13] 王宁, 刘丹, 谢敏伟, 等. 水环境中纳米氧化锌的环境行为及生物毒性研究进展[J]. 环境化学, 2016, 35(12):2528-2534.
[13] Wang N, Liu D, Xie M W, et al. Behavior and toxicity of zinc oxide nanoparticles in aquatic environment[J]. Environmental Chemistry, 2016, 35(12):2528-2534.
[14] Reshma V G, Mohanan P V. Cellular interactions of zinc oxide nanoparticles with human embryonic kidney (HEK 293) cells[J]. Colloids and Surfaces B (Biointerfaces), 2017, 157:182-190.
[15] Sembratowicz I, Ognik K, Stepniowska A. A evaluation of in vitro intestinal absorption of iron, calcium and potassium in chickens receiving gold nanoparticles[J]. British Poultry Science, 2016, 57(4):559-565.
[16] Hara H, Onoshima S, Nakagawa C. Difructose an hydride Ⅲ promotes iron absorption in the rat large intestine[J]. Nutrition, 2010, 26(1):120-127.
[17] Mortimer M, Kasemets K, Kahru A. Toxicity of ZnO and CuO nanoparticles to ciliated protozoa tetrahymena thermophila[J]. Toxicology, 2010, 269:182-189.
[18] Espinoza A, Le B S, Olivares M, et al. Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA[J]. Biological Trace Element Research, 2012, 146(2):281-286.
[19] Salovaara S, Sanderg A, Andlid T, et al. Organic acids influence iron uptake in the human epithelial cell line Caco-2[J]. Journal of Agricultural and Food Chemistry, 2002, 50(21):6233-6238.
Options
Outlines

/

〈 〉