Abstract: P311 was identified by suppressive subtraction hybridization as potentially involved in smooth muscle myogenesis. The P311 expression is regulated at multiple levels by pathways that control cellular transformation. It has been demonstrated in the literature that metallothionein ⅡA （MT2A） is associated with the expression of P311, and it is critical in the regulation. Therefore, it has been considered that interaction between P311 and MT2A exists. A 3D model of P311 protein by homology modeling is constructed, and the related residues for interaction are analyzed with Autodock 4.0. The results show that amino acids such as GLU14, SER48 and GLU56 are important in binding, which forms a basis for further experiments.

Key words: docking, homology modeling, metallothionein ⅡA (MT2A) protein, P311 protein