Journal of Shanghai University(Natural Science Edition) ›› 2017, Vol. 23 ›› Issue (2): 169-178.doi: 10.3969/j.issn.1007-2861.2017.01.007

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Advancement of photosensitizers for photodynamic therapy

HAN Xiaobo, ZHENG Yinghong, YANG Liming   

  1. Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China
  • Received:2016-12-26 Online:2017-04-30 Published:2017-04-30

Abstract:

This paper reviews the main types of photosensitizers in photodynamic therapy(PDT). PDT has been widely used in the treatment of tumors and non neoplastic diseases since its invention. In a photochemical reaction, a material is called photosensitizer if it can be activated by light with energy transferred to reactants without reaction. Photosensitizer is an important impact factor in PDT, and its research progress is important in the development of PDT. Photosensitizer has three generations: the first dominated by hematoporphyrin derivative, the second represented by porphyrin and porphin, and the third being modification of the second generation chemical groups. After decades of development, chemical properties of photosensitizer has become stable with less side effects.

Key words:  photodynamic therapy ,  phthalocyanin ,  porphyrin ,  upconversion nanoparticles, photosensitizer