运动训练对心脏衰老的保护机制

doi:10.12066/j.issn.1007-2861.1968

Abstract

Abstract:

To investigate cardio protective effects of exercise training in advanced cardiac aging. Mice were subjected to intraperitoneal injection of D-galactose (D-gal) to induce ageing, and trained using a 4-month running protocol. Heart index, mitochondrial biogenesis, energy metabolism and DNA damage were determined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). This work shows that exercise training protected heart index, increased mitochondrial DNA replication and transcription, activated the PGC-1α signal, and decreased the DNA damage in ageing heart. In conclusion, exercise training protects against ageing-induced cardiac dysfunction through enhancing energy metabolism, improving mitochondrial biogenesis and reducing DNA damage.

TAO Lichan, JIA Fang. Mechanism of exercise training in protection against cardiac aging[J]. Journal of Shanghai University（Natural Science Edition）, 2017, 23(6): 828-.

References

[1] Strait J B, Lakatta E G. Aging-associated cardiovascular changes and their relationship to heart failure [J]. Heart Failure Clinics, 2012, 8(1): 143-164.

[2] Misaka T, Suzuki S, Miyata M, et al. Deficiency of senescence marker protein 30 exacerbates angiotensin Ⅱ-induced cardiac remodelling [J]. Cardiovascular Research, 2013, 99(3): 461-470.

[3] Kwak H B. Aging, exercise, and extracellular matrix in the heart [J]. Journal of Exercise Rehabilitation, 2013, 9(3): 338-347.

[4] Kwak H B. Effects of aging and exercise training on apoptosis in the heart [J]. Journal of Exercise Rehabilitation, 2013, 9(2): 212-219.

[5] Bergmann O, Bhardwaj R D, Bernard S, et al. Evidence for cardiomyocyte renewal in humans [J]. Science, 2009, 324(5923): 98-102.

[6] Weiner R B, Baggish A L. Exercise-induced cardiac remodeling [J]. Progress in Cardiovascular Diseases, 2012, 54(5): 380-386.

[7] Ellison G M, Waring C D, Vicinanza C, et al. Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms [J]. Heart, 2012, 98(1): 5-10.

[8] Mann N, Rosenzweig A. Can exercise teach us how to treat heart disease? [J]. Circulation, 2012, 126(22): 2625-2635.

[9] Lai C H, Ho T J, Kuo W W, et al. Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis [J]. AGE, 2014, 36(5): 9706-9709.

[10] Ozturk N, Olgar Y, Er H, et al. Swimming exercise reverses aging-related contractile abnormalities of female heart by improving structural alterations [J]. Cardiology Journal, 2017, 24(1): 85-93.

[11] Kumar A, Dogra S, Prakash A. Effect of carvedilol on behavioral, mitochondrial dysfunction, and oxidative damage against D-galactose induced senescence in mice [J]. Naunyn Schmiedeberg’s

Archives of Pharmacology, 2009, 380(5): 431-441.

[12] Wang W, Li S, Dong H P, et al. Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging [J]. Life Sciences, 2009, 85(3/4): 127-135.

[13] Zhang Y, Mi S L, Hu N, et al. Mitochondrial aldehyde dehydrogenase 2 accentuates aginginduced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function [J]. Free Radical Biology & Medicine, 2014, 71: 208-220.

Mechanism of exercise training in protection against cardiac aging

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