抗抑郁药阿米替林的电子束辐照降解行为

doi:10.12066/j.issn.1007-2861.1955

Abstract

Abstract:

Antidepressants are an important part of pharmaceutical contaminants that are new pollutants becoming potential threat to the environment. The existing sewage treatment techniques can hardly treat them effectively. This study focuses on the application of electron beam irradiation to degradation of antidepressant amitriptyline (AMI). The influencing factors include initial concentration, irradiation dose, pH, amount of H$_{2}$O$_{2}$, various atmosphere conditions and different ions. The degradation behavior of AMI in real water environment was simulated, and possible degradation paths were proposed according to the product analysis. The above mentioned factors have shown important influences on the irradiation degradation of AMI. Degradation of target AMI obeyed the pseudo first-order kinetic equation. When the dose of irradiation was 5 kGy, the target pollutant was completely degraded, meaning that electron beam irradiation is an effective means to treat wastewater containing AMI.

Key words: antidepressant, amitriptyline, electron beam irradiation, degradation

CLC Number:

X171.5

Fei DENG, Xu LI, Debao YUAN, Tao ZHAO, Wen MAO, Minghong WU, Gang XU. Degradation behavior of antidepressant amitriptyline under electron beam irradiation[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(6): 933-942.

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://www.journal.shu.edu.cn/EN/10.12066/j.issn.1007-2861.1955

https://www.journal.shu.edu.cn/EN/Y2019/V25/I6/933

Figures/Tables 11

Fig.1

Fig.2

Table 1

Fig.3

Table 2

Fig.4

Table 3

Fig.5

Fig.6

Fig.7

Fig.8

References 20

[1]	Petrie B, Barden R, Kasprzyk-Hordern B . A review on emerging contaminants in wastewaters and the environment: Current knowledge, understudied areas and recommendations for future monitoring[J]. Water research, 2015,72:3-27.
[2]	Baker D R, Kasprzyk-Hordern B . Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography--positive electrospray ionisation tandem mass spectrometry[J]. Journal of Chromatography A, 2011,1218(12):1620-1631.
[3]	Calisto V, Esteves V I . Psychiatric pharmaceuticals in the environment[J]. Chemosphere, 2009,77(10):1257-1274.
[4]	Lajeunesse A, Smyth S A, Barclay K , et al. Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada[J]. Water research, 2012,46(17):5600-5612.
[5]	Ziarrusta H, Mijangos L, Prieto A , et al. Determination of tricyclic antidepressants in biota tissue and environmental waters by liquid chromatography-tandem mass spectrometry[J]. Analytical and bioanalytical chemistry, 2016,408(4):1205-1216.
[6]	Lajeunesse A, Gagnon C, Sauve S . Determination of basic antidepressants and their n-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography—Tandem mass spectrometry[J]. Analytical chemistry, 2008,80(14):5325-5333.
[7]	Togola A, Budzinski H . Multi-residue analysis of pharmaceutical compounds in aqueous samples[J]. Journal of Chromatography A, 2008,1177(1):150-158.
[8]	Wu M H, Xiang J J, Que C J , et al. Occurrence and fate of psychiatric pharmaceuticals in the urban water system of Shanghai, China[J]. Chemosphere, 2015,138:486-493.
[9]	Minguez L, Farcy E, Ballandonne C , et al. Acute toxicity of 8 antidepressants: What are their modes of action?[J]. Chemosphere, 2014,108:314-319.
[10]	Yang M, Qiu W H, Chen J S , et al. Growth inhibition and coordinated physiological regulation of zebrafish (Danio rerio) embryos upon sublethal exposure to antidepressant amitriptyline[J]. Aquatic toxicology, 2014,151:68-76.
[11]	Tadkaew N, Hai F I, Mcdonald J A , et al. Removal of trace organics by MBR treatment: The role of molecular properties[J]. Water research, 2011,45(8):2439-2451.
[12]	Tsai Y L, Chang P H, Gao Z Y , et al. Amitriptyline removal using palygorskite clay[J]. Chemosphere, 2016,155:292-199.
[13]	刘宁, 徐刚, 吴明红 , 等. 邻苯二甲酸二丁酯的电子束辐射降解[J]. 核技术, 2008(3):209-213.
[14]	吴明红, 徐刚, 刘宁 , 等. 电子束辐照处理难降解有机污染物[J]. 上海大学学报(自然科学版), 2011,17(4):549-554.
[15]	Liu N, Wang T, Zheng M , et al. Radiation induced degradation of antiepileptic drug primidone in aqueous solution[J]. Chemical Engineering Journal, 2015,270:66-72.
[16]	Ismail M, Khan H M, Sayed M , et al. Advanced oxidation for the treatment of chlorpyrifos in aqueous solution[J]. Chemosphere, 2013,93(4):645-651.
[17]	Zheng B G, Zheng Z, Zhang J B , et al. Degradation of the emerging contaminant ibuprofen in aqueous solution by gamma irradiation[J]. Desalination, 2011,276(1/3):379-385.
[18]	Buxton G V, Greenstock C L, Helman W P , et al. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals ($\cdot$OH/$\cdot$O$^-$) in aqueous solution[J]. J Phys Chem Ref Data, 1988,17(2):513-886.
[19]	Zheng M, Xu G, Pei J C , et al. EB-radiolysis of carbamazepine: in pure-water with different ions and in surface water[J]. Journal of Radioanalytical and Nuclear Chemistry, 2014,302(1):139-147.
[20]	Abbar J C, Lamani S D, Nandibewoor S T . Ruthenium(III) catalyzed oxidative degradation of amitriptyline-A tricyclic antidepressant drug by permanganate in aqueous acidic medium[J]. Journal of Solution Chemistry, 2011,40(3):502-520.

Degradation behavior of antidepressant amitriptyline under electron beam irradiation

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 11

References 20

Related Articles 13

Recommended Articles

Metrics

Comments

[1]	WANG Xinyan, GUO Xiaohan, MA Genwang, GAI Weizhuo, DENG Zhenyan. Oxytetracycline removal from aqueous solution using a hydroxyl radical ﬁltrate containing highly active aluminum ions [J]. Journal of Shanghai University（Natural Science Edition）, 2025, 31(2): 252-263.
[2]	Haoran Zhao, Wei Peng, Bingli Lei, Lanbing Xu, Mengjie Xu. Biological eﬀects of typical antidepressants on SKBR3/MCF-7 human breast cancer cells [J]. Journal of Shanghai University（Natural Science Edition）, 2023, 29(2): 264-.
[3]	YANG Shuxian, HU Xing. Degradation characteristics of biodegradation of tetrabromobisphenol A by the novel aerobic strain W1-2 [J]. Journal of Shanghai University（Natural Science Edition）, 2022, 28(1): 57-66.
[4]	GAO Pengfei, OU Zhenghai, QIN Juan, SHI Weimin, WANG Linjun. Effects of electron beam irradiation on microstructures and thermoelectric power factors of β-Zn₄Sb₃ thin films [J]. Journal of Shanghai University（Natural Science Edition）, 2020, 26(6): 937-944.
[5]	Chenzi LIU, Yemin HU, Wenxian LI, Yang LIU, Pengfei HU, Hongming JIN, Mingyuan ZHU, Ying LI. Mechanism of capacity degradation of β-NaMnO₂ as cathode material for sodium ion battery [J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(5): 776-785.
[6]	YUAN Debao, DENG Fei, MAO Wen, ZHAO Tao, HU Mian, WU Minghong, XU Gang. Degradation of sulfamethoxazole in aqueous solution by electron beam [J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(1): 101-108.
[7]	ZHANG Yunlong, PU Xianjuan, CHENG Lingli, JIANG Yong, DING Guoji, JIAO Zheng. Enhanced g-C₃N₄ photocatalyst with vacuum heating and electron beam irradiation [J]. Journal of Shanghai University（Natural Science Edition）, 2017, 23(3): 452-463.
[8]	HU Xing, DU Liting, WANG Fei, BAI Xiaoqing, LIU Xuelan, YANG Yang. null [J]. Journal of Shanghai University（Natural Science Edition）, 2016, 22(2): 188-196.
[9]	XU Pei-jun, BAO Yang-yang, ZHENG Ming, XU Gang, WU Ming-hong. Degradation of Procion Red MX-5B in aqueous solution using electron beam [J]. Journal of Shanghai University（Natural Science Edition）, 2015, 21(6): 694-700.
[10]	WANG Qian, LIU Xiao-yan, WEI Jing, LI Hong-bing, LI Xin, HUANG Yi-ning, XIA Jing. Pyrene Degradation Effect with Celery Root in Combined Pollution Soil in Simulated Wetland [J]. Journal of Shanghai University（Natural Science Edition）, 2013, 19(4): 363-367.
[11]	ZHANG Jun-ya,SONG Ren-tao,XU Zheng-kai,ZHU Chen-guang. Construction and Characterization of Bacterial Artificial Chromosome Library of Cupriavidus necator JMP134 [J]. Journal of Shanghai University（Natural Science Edition）, 2011, 17(5): 675-680.
[12]	WU Ming-hong,XU Gang,LIU Ning,MA Jing,WANG Jin-hua,TANG Liang,WANG Liang. Radiolytic Degradation of Persistent Organic Pollutants by Electron Beam Irradiation [J]. Journal of Shanghai University（Natural Science Edition）, 2011, 17(4): 549-554.
[13]	LIU Xiao-Yan-1, LI Ying-Li-2, WANG Zhen-Zhen-1, WANG Jun-1, ZHANG Xin-Ying-1, TIAN Xiang-1, ZHAO Yue-1. Degradation of Petroleum Pollutants in Saline-Alkali Soils Using Aboriginal Microbe [J]. Journal of Shanghai University（Natural Science Edition）, 2010, 16(5): 460-464.