收稿日期: 2019-04-08
网络出版日期: 2019-06-24
基金资助
国家自然科学基金青年科学基金资助项目(81700506)
Role of regulation of ABCG1 gene expression in cardiovascular diseases
Received date: 2019-04-08
Online published: 2019-06-24
胆固醇流出作为胆固醇逆向运输的第一步, 是维持细胞稳态的重要机制.三磷酸腺苷结合盒转运蛋白G1 (adenosine triphophate (ATP)-binding cassette (ABC) transporter G1, ABCG1) 能够促进细胞内胆固醇流出至胞外的高密度脂蛋白, 参与维持细胞胆固醇动态平衡, 在动脉粥样硬化、肥胖以及糖尿病等多种疾病中发挥重要作用.ABCG1 的基因表达受多重因素调控,如转录因子、蛋白修饰、DNA 甲基化及小分子核糖核酸的调控,进而影响多种疾病的发生发展.主要针对 ABCG1 及其表达调控在心血管疾病中的作用作一综述,以期为该领域的研究提供新的方向.
关键词： 三磷酸腺苷结合盒转运蛋白G1; 心血管疾病; 胆固醇; 基因表达
师莹, 姚柳, 艾玎 . ABCG1 基因表达调控在心血管疾病中的作用[J]. 上海大学学报(自然科学版), 2019 , 25(3) : 415 -424 . DOI: 10.12066/j.issn.1007-2861.2133
Cholesterol efflux, the first step in reverse cholesterol transport, is an important mechanism for maintaining cell homeostasis. Adenosine triphophate (ATP)-binding cassette (ABC) transporter G1 (ABCG1) maintains cellular cholesterol homeostasis by promoting intracellular cholesterol efflux to high density lipoprotein and it plays a crucial role in atherosclerosis, obesity and diabetes. The expression of ABCG1 is regulated by several factors, including transcript factor, protein modification, DNA methylation and microRNA, and subsequently it contributes to the development of several diseases. In this paper, the role of ABCG1 and its regulation in cardiovascular diseases have been reviewed, and it is hoped that exploration into this area will help bring about new ideas for the research in this field.
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