收稿日期: 2019-05-27
网络出版日期: 2019-06-24
基金资助
国家自然科学基金资助项目(31730112);国家自然科学基金资助项目(91639302);国家自然科学基金资助项目(31625019);国家自然科学基金资助项目(91849202);中国科学院战略性先导计划资助项目(XDB19000000);中国科学院战略性先导计划资助项目(XDA16020204)
The proliferation and regulation of a adult mammalian cardiomyocytes
Received date: 2019-05-27
Online published: 2019-06-24
刘秀秀, 周斌 . 成体哺乳动物心肌细胞增殖及其调控[J]. 上海大学学报(自然科学版), 2019 , 25(3) : 365 -374 . DOI: 10.12066/j.issn.1007-2861.2141
Cardiomyocytes, a kind of completely differentiated cells, are believed not to be able to proliferate. Recent studies indicate, however, that adult mammalian cardiomyocytes turn over at a certain rate. These studies use different approaches including isotype incorporation and genetic knock-in mice lineage tracing. Cardiomyocyte proliferation may be regulated by complicated molecular network as well as varied environment or microenvironment. Special characteristic features in cardiomyocytes themselves also have an impact on their proliferation.
Key words： proliferation; cardiomyocyte; regulation; adult mammalian
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