HIV在人体免疫网络中传播的动力学研究
收稿日期: 2016-03-10
网络出版日期: 2017-12-30
基金资助
国家自然科学基金资助项目(11271246)
Dynamics of HIV spreading in network of immune system in vivo
Received date: 2016-03-10
Online published: 2017-12-30
虽然抗逆转录病毒疗法(antiretroviral therapy, ART)能够有效地抑制人类免疫缺陷病毒(human immunodeficiency virus, HIV)的复制, 但病毒血症现象依然存在. 基于此, 主要探讨病毒避难所是否存在. 研究发现: 由于存在血脑屏障, 在接受治疗的状况下, 大脑中的病毒载量仍然保持在较高稳态, 表明大脑确是HIV病毒的避难所; 外周血中的病毒水平并不能正确反映身体内其他组织中的病毒载量状况.
黄颖, 娄洁 . HIV在人体免疫网络中传播的动力学研究[J]. 上海大学学报(自然科学版), 2017 , 23(6) : 920 . DOI: 10.12066/j.issn.1007-2861.1808
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus (HIV), body virus sanctuary seems to exist. This study
explores whether the virus sanctuary does exist. Our findings show that, due to bloodbrain barrier, viral load in brain remains at a high steady state even antiviral therapy is followed. This suggests that brain is the sanctuary of HIV virus. In addition, we have also found that level of virus in the peripheral blood may not correctly reflect what is occurring inside the body.
[1] Shen L, Siliciano R F. Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection [J]. Journal of Allergy and Clinical Immunol,
2008, 122(1): 22-28.
[2] Perelson A S, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy [J]. Nature, 1997, 387(6629): 188-191.
[3] Haase A T, Henry K, Zupancic M, et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue [J]. Science, 1996, 274(5289): 985-989.
[4] Hamed K A, Winters M A, Holodniy M. et al. Detection of human immunodeficiency virus type 1 in semen: effects of disease stage and nucleoside therapy [J]. Journal of Infectious Diseases, 1993, 167(4): 798-802.
[5] Vernazza P L, Eron J J, CohenMS, et al. Detection and biologic characterization of infectious HIV-1 in semen of seropositive men [J]. AIDS, 1994, 8(9): 1325-1329.
[6] Levy J A. HIV and the pathogenesis of AIDS [M]. 3rd ed. Washington: ASM Press, 2007.
[7] Barker C F, Billingham R E. Immunologically privileged sites [J]. Advances in Immunology, 1978, 25: 1-54.
[8] Callaway D S, Perelson A S. HIV-1 infection and low steady state viral loads [J]. Bulletin of Mathematical Biology, 2002, 64(1): 29-64.
[9] van den Driessche P, Watmough J. Reproduction numbers and sub-threshold endemic equilibrium for compartmental models of disease transmission [J]. Mathematical Biosciences, 2002, 180(1/2): 29-48.
[10] Blower S M, Gershengorn H B, Grant R M. A tale of two futures: HIV and antiretroviral therapy in San Francisco [J]. Science, 2000, 287(5453): 650-654.
[11] Lou J, Lou Y J, Wu J H. Threshold virus dynamics with impulsive antiretroviral drug effects[J]. Journal of Mathematical Biology, 2012, 65(4): 623-652.
[12] Perelson A S, Essvnger P, Cao Y, et al. Decay characteristics of HIV-infected compartments during combination therapy [J]. Nature, 1997, 387(6629): 188-191.
/
| 〈 |
|
〉 |
