HIV在人体免疫网络中传播的动力学研究

doi:10.12066/j.issn.1007-2861.1808

上海大学学报(自然科学版) ›› 2017, Vol. 23 ›› Issue (6): 920-.doi: 10.12066/j.issn.1007-2861.1808

HIV在人体免疫网络中传播的动力学研究

黄颖, 娄洁

上海大学理学院, 上海 200444

收稿日期:2016-03-10 出版日期:2017-12-30 发布日期:2017-12-30
通讯作者: 娄洁(1973—), 女, 副教授, 博士, 研究方向为生物数学. E-mail: jie.lou@126.com
作者简介:娄洁(1973—), 女, 副教授, 博士, 研究方向为生物数学. E-mail: jie.lou@126.com
基金资助:
国家自然科学基金资助项目(11271246)

Dynamics of HIV spreading in network of immune system in vivo

HUANG Ying, LOU Jie

College of Sciences, Shanghai University, Shanghai 200444, China

Received:2016-03-10 Online:2017-12-30 Published:2017-12-30

摘要/Abstract

摘要：

虽然抗逆转录病毒疗法(antiretroviral therapy, ART)能够有效地抑制人类免疫缺陷病毒(human immunodeficiency virus, HIV)的复制, 但病毒血症现象依然存在. 基于此, 主要探讨病毒避难所是否存在. 研究发现: 由于存在血脑屏障, 在接受治疗的状况下, 大脑中的病毒载量仍然保持在较高稳态, 表明大脑确是HIV病毒的避难所; 外周血中的病毒水平并不能正确反映身体内其他组织中的病毒载量状况.

关键词: ART), HIV), 基本再生数, 抗逆转录病毒疗法(antiretroviral therapy, 淋巴细胞再循环, 人类免疫缺陷病毒(human immunodeficiency virus

Abstract:

Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus (HIV), body virus sanctuary seems to exist. This study
explores whether the virus sanctuary does exist. Our findings show that, due to bloodbrain barrier, viral load in brain remains at a high steady state even antiviral therapy is followed. This suggests that brain is the sanctuary of HIV virus. In addition, we have also found that level of virus in the peripheral blood may not correctly reflect what is occurring inside the body.

Key words: antiretroviral therapy (ART), lymphocyte recirculation, reproduction number, human immunodeficiency virus (HIV)

黄颖, 娄洁. HIV在人体免疫网络中传播的动力学研究[J]. 上海大学学报(自然科学版), 2017, 23(6): 920-.

HUANG Ying, LOU Jie. Dynamics of HIV spreading in network of immune system in vivo[J]. Journal of Shanghai University（Natural Science Edition）, 2017, 23(6): 920-.

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HIV在人体免疫网络中传播的动力学研究

Dynamics of HIV spreading in network of immune system in vivo

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