收稿日期: 2016-04-22
网络出版日期: 2016-06-30
基金资助
国家自然科学基金资助项目(81570247)
Circulating miR-21-3p as biomarkers for sepsis-induced cardiomyopathy
Received date: 2016-04-22
Online published: 2016-06-30
已有研究发现微小RNA(microRNAs, miRNAs) 可由细胞分泌并释放进入循环系统, 在血清、血浆、尿液和其他体液中稳定存在, 并可作为非损伤性生物标记物对多种疾病进行早期诊断、鉴别分期、预后判断和疗效监测等. 与健康对照者相比, miR-21-3p 在22 例脓毒症心衰患者血浆中显著升高. 通过绘制受试者工作特征(receiver operating characteristic, ROC)曲线, 并分析其与临床参数的相关性发现, miR-21-3p 在鉴别脓毒症心衰和健康人群时, 曲线下面积(area under the curve, AUC)为0.949. 相关性分析结果显示, 血浆miR-21-3p水平与B 型脑钠肽(brain natriuretic peptide, BNP)(r = 0.968, P < 0.001)、心肌肌钙蛋白T (cardiac troponin T, cTNT)(r = 0.257, P = 0.002)水平呈正相关. 因此, 外周血中的miR-21-3p有作为脓毒症心肌病的生物标记物的潜力.
刘慧, 王惠, 史倞, 孔祥清 . 循环血miR-21-3p作为脓毒症心肌病的标记物[J]. 上海大学学报(自然科学版), 2016 , 22(3) : 366 -370 . DOI: 10.3969/j.issn.1007-2861.2016.03.019
Recently, microRNAs(miRNAs) are found to be abundantly present in body fluids including plasma and serum, and called circulating miRNAs. Increasing evidences suggest that circulating miRNAs may be useful as stable blood-based biomarkers in sepsis. Serum miR-21-3p is significantly increased in septic patients compared with healthy controls. Receiver operating characteristic (ROC) curve analyses suggest that these plasma miR-21-3p may be useful biomarkers for discriminating patients with sepsis-induced cardiomyopathy (SIC) from healthy controls. miR-21-3p yields the ROC area under the curve
(AUC) of 0.949. Further analyses indicate that the expression level of miR-21-3p is correlated with the brain natriuretic peptide (BNP) (r = 0.968, P < 0.001) and cardiac troponin T (cTNT) level (r = 0.257, P = 0.002). Serum miR-21-3p may serve as new biomarkers for sepsis with high specificity and sensitivity.
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