非编码 RNA 调控肝癌的研究进展

杨芊芊, 田 慧, 王广志, 马中良

doi:10.12066/j.issn.1007-2861.2457

上海大学学报(自然科学版) >

2023 , Vol. 29 >Issue 2: 211

DOI: https://doi.org/10.12066/j.issn.1007-2861.2457

非编码 RNA 调控肝癌的研究进展

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1. 上海大学生命科学学院非编码RNA与癌症实验室, 上海200444; 2. 复旦大学附属中山医院, 上海200032; 3. 潍坊医学院附属医院, 山东潍坊261053)

收稿日期: 2022-09-17

网络出版日期: 2023-04-30

基金资助

上海市创新行动计划资助项目(20S11901300); 山东省医药卫生科技发展资助项目(2019WS596)

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Research progress of non-coding RNAs in liver cancer

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1. Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China; 2. Zhongshan Hospital, Fudan University, Shanghai 200032, China; 3. A±liated Hospital of Weifang Medical University, Weifang 261053, Shandong, China

Received date: 2022-09-17

Online published: 2023-04-30

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摘要

肝癌是全球领先的致命恶性肿瘤. 缺氧是肿瘤微环境(tumor microenvironment, TME) 的显著特征, 缺氧诱导因子-1a (hypoxia-inducible factor 1a, HIF-1a) 是缺氧反应中重要的转录调节因子. 非编码RNA (non-coding RNA, ncRNA) 在调控肝癌的发病机制和进展方面起着重要的作用. 综述了缺氧环境下ncRNA 在肝癌发生、上皮间质转化和血管形成中的病理作用, 并讨论了ncRNA 作为人类肝细胞癌(hepatocellular carcinoma, HCC) 诊断工具和治疗靶点的潜在应用.

关键词： HIF-1a; 非编码RNA; 肝癌; 肿瘤微环境

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杨芊芊, 田慧, 王广志, 马中良 . 非编码 RNA 调控肝癌的研究进展[J]. 上海大学学报(自然科学版), 2023 , 29(2) : 211 . DOI: 10.12066/j.issn.1007-2861.2457

Abstract

Liver cancer is the leading global lethal malignancy. Hypoxia in the tumor microenvironment is a hallmark of the tumor microenvironment, and hypoxia-inducible factor-1a is the most important transcriptional regulator in response to hypoxia. Non- coding RNA (ncRNA) play a crucial role in regulating the pathogenesis and progression of hepatocellular carcinoma (HCC). This review comprehensively summarizes the pathological roles of ncRNA in hepatocarcinogenesis, epithelial-mesenchymal transition, and angiogen- esis under hypoxic environments, and discusses the potential applications of ncRNA as diagnostic tools and therapeutic targets for human HCC.

Key words： HIF-1a; non-coding RNA; liver cancer; tumor microenvironment

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